Simethicone containing pharmaceutical compositions

Details Simethicone containing pharmaceutical compositions Simethicone containing pharmaceutical compositions

1995-05-31

1997-10-21

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424471, 424470, 424458, 424459, 424490, 424461, 424462, 424469, A61K 924, A61K 926, A61K 952

Patent

active

056793766

ABSTRACT:
A solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier which is substantially impermeable to simethicone.

REFERENCES:
patent: 3767794 (1973-10-01), McVean et al.
patent: 4127650 (1978-11-01), Buchler
patent: 4198390 (1980-04-01), Rider
patent: 4316888 (1982-02-01), Nelson
patent: 4396604 (1983-08-01), Mitra
patent: 4857324 (1989-08-01), Mir et al.
patent: 5075114 (1991-12-01), Roche
J. Alfred Rider, "An Improved Simethicone Antacid Tablet", pp. 1033-1038 (1981).
F. Maksoud, S.A. Said and M. Gourab, "Simethicone Use in Antacid Medications", pp. 35 and 36 (1976).
J.K. Lalla and M.A. Sarkar, "Preparation and Stability Testing of Simethicone Emulsion", pp. 159-166 (1985).
Cellulose Esters Polymer Characterization, Bulleltin CE-2, FMC Corp. (1987).
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CA115(24):263465f, Pharmaceutical Composition for Treating Gastrointestinal Distress (1991).
CA111(2):12462a, Incorporation of Simethicone into Syrupy or Clear Base Liquid Orals (1989).
CA97(13): 103890x, The Effect of Activated Dimethicone and an Proprietary Antacid Preparation Containing this Agent on the Absorption of Phenytoin (1982).
CA96(25):210465p, The Effect of Activated Dimethicone, Other Antacid Constituents, and Kaolin on the Absorption of Propranolol (1982).
CA93(14):138018p, Uniform Beadlike Particles Forming a Powder Surpuriya (1980).
CA90(17):132533u, Interaction of Digoxin with Activated Dimethicone and Other Antacid Constituents (1979).
CA107(4):28386g, Drugs in Combined Gastro-Soluble and Gastro-Resistant Form (1986).
C71-S36634, Flatulence Treatment with Antifoaming--Compn (1974).
C75-W80496, Medicaments for Treating Nervous Hyperacidity, Etc.--Contg. a Psychosedative, an Antacid, and an Antiflatuent (1975).

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