Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine

Details Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine

1976-03-11

1977-05-17

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

536 23, 260260, C07D23952

Patent

active

040241432

ABSTRACT:
A process for producing bis-silyl derivatives of fluorinated pyrimidines is disclosed, wherein a 5-fluoro-6-hydroxy or alkoxy pyrimidine is reacted with a silane, such as triethylchlorosilane. The intermediate product produced by that reaction, which is obtained in high yield, may then be reacted with a further compound, which can be a blocked sugar halide or 2-chlorotetrahydrofuran, to produce a nucleoside of the pyrimidine. The nucleosides are useful as antibacterial and antiviral agents, and in the treatment of cancer.

REFERENCES:
patent: 3354160 (1967-11-01), Duschinsky et al.
patent: 3635946 (1972-01-01), Giller et al.

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