Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing
Patent
1980-09-24
1981-09-22
Shaver, Paul F.
Organic compounds -- part of the class 532-570 series
Organic compounds
Silicon containing
560 56, C07F 708, C07F 704
Patent
active
042911680
ABSTRACT:
Indanyloxy compounds having 2-alkynyl substituents which exhibit diuretic, saluretic, and uricosuric activity are described. The compounds are obtained according to a process involving selective etherification of a 5-hydroxyindanone followed by alkynylation with a silylated alkynyl bromide to provide novel silylated intermediates which are hydrolyzed to indanyloxy compounds such as (6,7-dichloro-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic acid.
REFERENCES:
patent: 3984465 (1976-10-01), Cragoe et al.
patent: 4070539 (1978-01-01), Cragoe
patent: 4096267 (1978-06-01), Cragoe et al.
deSolms et al., "J. Med. Chem.", 21, pp. 437-443, 1978.
Woltersdorf et al., "J. Med. Chem.", 20, pp. 1400-1408, 1977.
Johnson Porter C.
Matier William L.
Carnahan Robert E.
Mead Johnson & Company
Shaver Paul F.
Uloth Robert H.
LandOfFree
Silylated indanyloxyacetates does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Silylated indanyloxyacetates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Silylated indanyloxyacetates will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-336294