Silver-based pharmaceutical compositions

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants

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Details

424 7834, 424404, 424409, 424411, 424422, 424423, 424430, 424434, 424446, 424447, 424618, 6048901, A01N 2502, A01N 5916

Patent

active

057441510

ABSTRACT:
The present invention relates to pharmaceutical compositions which are photostable and antimicrobially active comprising one or more medicinal agents and a stabilized ionized silver-based antimicrobial composition. The stabilized ionized silver-based antimicrobial composition comprises a stabilizing acyclic polyether polymer, cations, and anions present in excess with regard to the amount of cations. Methods for making and using the pharmaceutical compositions are also described. These pharmaceutical compositions are useful in the prevention and treatment of infections and diseases.

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Lowbury et al., "Topical Chemoprophylaxis with Silver Sulphadizaine and Silver Nitrate Chlorhexidine Creams: Emergence of Sulphonamide-resistant Gram-negative Bacilli," British Medical Journal 1:493-496 (1976).
Russell et al., Antimicicrobial Activity and Action of Silver, Progress in Medicinal Chemistry 31:351-70 (1994).

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