Silicone vesicles and entrapment

Details Silicone vesicles and entrapment Silicone vesicles and entrapment

1994-03-14

1994-11-15

Foelak, Morton

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 424 59, 424 64, 424 761, 4284022, 514841, 514844, 521 76, A61K 951, A61K 3722

Patent

active

053646339

ABSTRACT:
A method of entrapping a water-soluble substance in vesicles formed from a siloxane surfactant is carried out by dissolving the substance to be entrapped in water, adding a siloxane surfactant, mildly agitating the mixture, and removing excess of water and substance. Water-insoluble substances can be entrapped in the vesicles by dissolving the substance to be entrapped in the siloxane surfactant, and mildly agitating the substance and the siloxane surfactant. Suitable siloxane surfactants are R--[Si(Me).sub.2 O].sub.14 --Si(Me).sub.2 --R in which R is --(CH.sub.2).sub.3 (OCH.sub.2 CH.sub.2).sub.7 OH, R--[Si(Me).sub.2 O].sub.14 --Si(Me).sub.2 --R in which R is --(CH.sub.2).sub.3 (OCH.sub.2 CH.sub.2).sub.12 OH, Me.sub.3 SiO[Si(Me).sub.2 O].sub.22 --[SiMeRO].sub.2 --SiMe.sub.3 in which R is --(CH.sub.2).sub.3 (OCH.sub.2 CH.sub.2).sub.12 OH, and Me.sub.3 SiO[Si(Me).sub.2 O].sub.103 --[SiMeRO].sub.10 --SiMe.sub.3 in which R is --(CH.sub.2).sub.3 (OCH.sub.2 CH.sub.2).sub.12 OH.

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