Silicone-hardened pharmaceutical microcapsules and process of ma

Plastic and nonmetallic article shaping or treating: processes – Encapsulating normally liquid material – Liquid encapsulation utilizing an emulsion or dispersion to...

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264 46, 42721332, 42721336, 514963, 424460, A61K 950

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active

050008862

ABSTRACT:
There is disclosed a process for preparing compositions comprising microcapsules by phase separation microencapsulation wherein the hardening agent employed is a volatile silicone fluid and with the compositions prepared thereby. The use of the volatile silicone fluid as a hardening agent permits the production of microcapsules substantially free of any alkane hardening agent, eliminating potential combustability problems of the prior art processes and toxicity problems of the prior art compositions.

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Lee R. Beck & Valerie Z. Pope, Controlled-Release Delivery Systems for Hormones A Review of their Properties & Current Therapeutic Use, Department of Obstetrics & Gynecology, Div. of Reproductive Biology & Endocrinology, Drugs 27: pp. 528-547 (1984).
R. G. Gupta & B. C. Rao, Microencapsulation of Vitamin B-12 by Emulsion Technique, Drug Development & Industrial Pharmacy, 11(1), 41-53 (1985).
S. Benita, J. P. Benoit, F. Puisieux and C. Thies, Characterization of Drug-Loaded Poly(d,1-lactide) Microspheres, Journal of Pharmaceutical Sciences/ pp. 1721-1724, vol. 73, No. 12, Dec., 1984.
Lee R. Beck, Ph.D., Donald R. Cowsar, Ph.D. & Valerie Z. Pope, M.S., Research Frontiers In Fertility Regulation, AID/DSPE-C-0035, pp. 1-17, vol. 1, No. 1, Jul. 1980.

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