Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Reexamination Certificate
1999-05-28
2001-03-13
Jarvis, William R. A. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
C514S770000
Reexamination Certificate
active
06200964
ABSTRACT:
BACKGROUND OF THE INVENTION
Acne is a condition of the human skin characterized by the excess flow of sebum from sebaceous glands. Excess sebum (e.g., skin oil) on the person's skin inhibits the flow of sebum from hair follicles, causing it to thicken and form a solid plug within the follicle known as a comedone. The formation of comedones stimulates hyperkeratinization, resulting in a closing of the follicle opening. The closed follicle usually results in either a papule, a pustule, or a cyst that becomes infected with bacteria such a p-acnes. This infection is known as acne, or in lesser severity, seborrhea.
Salicylic acid is a known keratolytic agent that has the ability to both penetrate and dissolved comedones as well as kill bacteria (e.g., p. acnes). Salicylic acid, however, has very limited solubility in water and, thus, has typically been formulated in oil-in-water pigmented cosmetic formulations. The use of the oil-in-water formulations, however, does not assist in the absorption of oil from the skin but, rather, just adds more oil to the person's skin.
The present invention relates a topical silicone gel or a topical composition containing the gel (e.g., a water-in-silicone cosmetic foundation). The gel comprises salicylic acid for the treatment of acne and seborrhea. The gel also provides the additional benefit of oil absorbing properties. The oil absorbing properties both assist in the treatment of acne and seborrhea by absorbing excess sebum. In addition, the gel produces a desirable smooth matte finish on the skin treatment area.
SUMMARY OF THE INVENTION
In one aspect, the invention features a silicone gel comprising a volatile liquid, a silicone polymer, and salicylic acid. In one embodiment, the silicone polymer is polysilicone-11. In one embodiment, the volatile liquid is a silicone fluid (e.g., cyclomethicone). In one embodiment, the silicone gel further comprises a second liquid (e.g., dimethicone or a solvent of salicylic acid). In one embodiment, the solvent is a non-alcohol solvent such as ester, e.g., neopentyl glycol dioctanoate/diisostearate, octyl salicylate, and octyl methoxycinnamate). In one embodiment, the silicone gel further comprises a porous silica (e.g., having a pore volume of 0.1 to about 1 ml/g, a particle diameter of between 1-20 microns, and/or an oil absorbence of between 10-500 ml/100 g). In one embodiment, the gel further comprises petrolatum. In one embodiment, the gel further comprises additional dermatologically active agents such as the anti-acne agents (e.g., benzoyl peroxide, resorcinol, sulfur, sodium borate, thymol, a retinoid, zinc sulfide, or zinc oxide), &agr;-, &bgr;-, and poly-hydroxy acids (e.g., lactic, glycolic, malic, tartaric, and citric acids) and/or anti-microbial or anti-inflammatory agents (e.g., alpha-bisabolol).
In one embodiment, the silicone gel comprises by weight: (a) about 1% to about 99% (e.g., about 10% to about 80%) of the volatile liquid (e.g., cyclomethicone); (b) about 1% to about 90% (e.g., about 10% to about 50%) of the silicone polymer (e.g., polysilicone-11); and (c) about 0.001% to about 50% (e.g., about 1% and about 30%) of the salicylic acid. In a further embodiment, the silicone gel further comprises by weight: (d) about 0.001% to about 50% (e.g., about 0.001% to about 30%) of dimethicone; (e) about 0.001% to about 50% (e.g., about 0.001% to about 30%) of neopentyl glycol dioctanoate/diisostearate; (f) about 0.001% to about 50% (e.g., about 0.001% to about 30%) of porous silica; and/or (g) about 0.001% to about 20% (e.g., about 0.001% to about 5%) of alpha-bisabolol.
In another aspect, the present invention features a composition comprising: (a) the above described silicone gel; and (b) a cosmetically acceptable carrier. In one embodiment, the cosmetically acceptable carrier comprises one or more of the members selected from the group consisting of acidifying agents, alkalizing agents, aerosol propellants, antimicrobial agents, antioxidants, buffering agents, chelating agents, coloring additives, dermotologically active agents, dispersing agents, emollients, emulsifying agents, humectants, fragrances, preservatives, sugars, sunscreen agents, surfactants, suspending agents, thickening agents, and vehicles.
In one embodiment, the composition is a water-in-silicone emulsion comprising by weight: (a) about 0.001% to about 90% (e.g., about 1% to about 50%) of the silicone gel; (b) about 0.001% to about 50% (e.g., about 5% to about 50%) of liquid silicone (e.g., cyclomethicone, dimethicone, or mixtures thereof); and (c) water, e.g., q.s. to 100%, by weight, once all the other ingredients have been added. In a further embodiment, the composition further comprises by weight: (d) about 0.001% to about 50% (e.g., about 0.001% to about 20%) of a humectant (e.g., dipropylene glycol); and (e) about 0.001% to about 50% (e.g., about 0.001% to about 20%) of sunscreen (e.g., titanium dioxide).
In another aspect, the present invention features method of treating (e.g., reducing or eliminating) or preventing acne and seborrhea (e.g., on the skin of a human), the method comprising applying to the skin of a subject an effective amount of the above mentioned silicone gel or composition. In one embodiment, the gel or composition is applied to the skin one to three times daily. When used in treating acne, the composition may be applied until the acne has been successfully treated (e.g., eliminated). When used as a prophylactic for acne, the composition may be applied daily until the risk of acne has subsided. The gel and composition may also be used to treat wrinkles, psoriasis, and hyperpigmentation, smooth skin, reduce skin lines, improve skin clarity and tone, and treat dandruff and seborrheic dermatitis (e.g., in a scalp cream, shampoo, or hair conditioner).
Other features and advantages of the present invention will be apparent from the detailed description of the invention and from the claims.
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Collins Carol J.
Singleton Laura C.
Woodin, Jr. Frederick W.
Jarvis William R. A.
Kim Vickie
McGowan William E.
Neutrogena Corporation
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