Silicon-containing solid support linker

Details Silicon-containing solid support linker Silicon-containing solid support linker

1997-06-25

1999-01-12

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

556418, 556489, 556465, 526279, 526296, 526336, 526346, 526342, 5263471, 5263472, 585469, 585601, 585733, C07F 708

Patent

active

058592776

ABSTRACT:
A compound of the formula ##STR1## where R is a solid support; R.sub.1 and R.sub.2 are alkyl, unsubstituted alkyl, or phenyl, and where R.sub.1 and R.sub.2 can be the same or different, for use in solid-phase synthesis.

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"A Silicon-Based Linker for Traceless Solid-Phase Synthesis," Matthew J. Plunkett and Jonathan A. Ellman, Department of Chemistry, University of California, J. Org. Chem. 1995, 60, 6006-6007.
"Bromination and Lithiation: Two Important Steps in the Functionalization of Polystyrene Resins," M. Jean Farrall and Jean M.J. Frechet, Dept. of Chemistry, University of Ottawa, J. Org. Chem., vol. 41, No. 24, 1976, 3877-3882.
"Polymer-anchored Organosilyl Protecting Group in Organic Synthesis," Tak-Hang Chan and Wen-Qiang Huang, Dept. of Chemistry, McGill Univ., J. Chem. Soc., Chem. Commun., 1985, 909-911.
"Synthesis and Applications of Small Molecule Libraries," Lorin A. Thompson and Jonathan A. Ellman, Dept. of Chemistry, Univ. of Calif., Chem. Rev. 1996, vol. 96 No. 1, 555-600.

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