Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Aluminum – calcium or magnesium element – or compound containing
Patent
1990-12-20
1993-11-23
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Aluminum, calcium or magnesium element, or compound containing
424724, 514917, 514951, 252184, A61K 3308, C01B 3312
Patent
active
052642259
DESCRIPTION:
BRIEF SUMMARY
The invention relates to a silicon-containing agent consisting of natural minerals with a loose structure and large surface, which can be used to decrease the load induced by radioactive isotopes and toxic heavy metals as well as a pharmaceutical composition containing the same agent as active ingredient.
Due to the continuously extending activities of the nuclear industries as well as to an increase in other industrial works, a sudden and unexpected occurrence of high amounts of toxic heaxy metals and radioactive isotopes endangering man and his environment, mainly after any disaster, should be taken into account. This can be a natural disaster or an industrial accident, e.g. the explosion of a nuclear reactor. Thus, one has to prepare himself for such cases and to find the means to reduce most effectively the occurring damages.
In the course of explosion of a nuclear power plant the radioactive isotopes get into the a , e.g. as gases or vapours or in a form bound to a liquid or solid carrier. From the air-space they get onto the soil, in the water, plants and indirectly or directly into the animals or men. It is commonly known that, depending on their amount, they can cause death, too. Thus, it is a very important task to collect these harmful isotopes and to remove same rapidly from the living beings or from the contaminated environment, respectively. The present invention has been developed in order to solve this task. Before the detailed description of the invention, the technical background will briefly be summarized by examples referring to the antecedents.
It has long been observed that diatomaceous earth, a natural loosely structured mineral essentially consisting of SiO.sub.2, which had been formed from the rests of minute, deceased living organisms, is capable to adsorb radioactive isotopes on its surface [J. Oglaza et. al.: Nukleonika 10, 519-522 (1965)].
It is also known that zeolite, a porous natural mineral with a solid skeleton but large surface is also able to bind metal ions, even radioactive metal isotopes. Based on this ability, it has been used for purifying water (European patent application No. 0,175,956 made open to public inspection).
According to Matsumura, Takashi, Ishiyama, Toshio (Radiation Center of Osaka Prefecture, Sakai): Annu. Rep. Radiat. Center Osaka Prefect. (Mar 1975), Vol. 15, p. 35-37 the decontamination property of the so-called manganese-zeolite, made from montmorillonite was studied. Each radioactive material was hardly removed at the contact time less than 20 min.
The selective removal and fixation of Cs and Sr have been studied in zeolite A and chabazite. The initial rate of Cs adsorption was fairly fast in chabazite but the adsorption ratio reached 100% within a few hours. Adsorption ratio of Sr in binderless A zeolite reached almost 100% after 15 h. (Mimura, Hitoshi, Kanno, Takuji: J. Nucl. Sci. Technol. (Tokyo) 1985 Vol. 22 (4) p. 284-291. Consequently, said zeolites are not really suitable for a quick and effective adsorption.
A high number of experiments was carried out with the above minerals to find an agent being able to bind harmful ions even in a high dilution in a rapid, effective and reliable manner and thereby to cure or improve the living or inanimate loaded environment.
It has been observed that the minerals mentioned above were particularly effective when their number in the agent was higher than one.
It has furthermore been recognized that, though these natural minerals were very good adsorbents for the harmful metals, their effectivity was surprisingly enhanced by a pretreatment before being composed to an agent.
For pretreatment the natural minerals are ground to a particle size of 0.001 to 0.5 mm and treated by a dilute acid, preferably hydrochloric acid solution. The dilute aqueous acid solution exerts also a purifying, loosening activity increasing the surface. The solution used for treatment may be an aqueous solution of 1 to 10% by weight, preferably 3% by weight. The ratio of the solution to the solid is usually 20 ml of solution related
REFERENCES:
patent: 3449492 (1969-06-01), Jensen
patent: 3687680 (1972-08-01), Krchnavi et al.
patent: 4563479 (1986-01-01), Feuer et al.
patent: 4610883 (1986-09-01), Laurent et al.
patent: 4698335 (1987-10-01), Spillert et al.
Chemical Abstracts, vol. 100, No. 6, Feb. 6, 1984, "Floatability of Zeolite with dodecylammonium acetate", Horioka et al.
Chemical Abstracts, vol. 77, No. 4, Jul. 24, 1972, "Polyethylene powder as a radioactive gas-absorbing agent," Danno et al.
Sztanyik Balint L.
Torocsik Mihaly
Varga Laszlo
Anthony Joseph D.
Argomen Agrarmenedzseri Kft.
Lovering Richard D.
Magyar Kulkereskedelmi Bank Rt.
Meller Michael N.
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