Silicon-based sleeve devices for chemical reactions

Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition

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422 8205, 422 8209, 422129, 422131, 4352851, 4352921, B01L 300

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active

055891365

ABSTRACT:
A silicon-based sleeve type chemical reaction chamber that combines heaters, such as doped polysilicon for heating, and bulk silicon for convection cooling. The reaction chamber combines a critical ratio of silicon and silicon nitride to the volume of material to be heated (e.g., a liquid) in order to provide uniform heating, yet low power requirements. The reaction chamber will also allow the introduction of a secondary tube (e.g., plastic) into the reaction sleeve that contains the reaction mixture thereby alleviating any potential materials incompatibility issues. The reaction chamber may be utilized in any chemical reaction system for synthesis or processing of organic, inorganic, or biochemical reactions, such as the polymerase chain reaction (PCR) and/or other DNA reactions, such as the ligase chain reaction, which are examples of a synthetic, thermal-cycling-based reaction. The reaction chamber may also be used in synthesis instruments, particularly those for DNA amplification and synthesis.

REFERENCES:
patent: 4315890 (1982-02-01), Tamers
patent: 4908112 (1990-03-01), Pace
patent: 5252294 (1993-10-01), Kroy et al.
patent: 5262127 (1993-11-01), Wise et al.
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5385709 (1995-01-01), Wise et al.
M. A. Northrup, "DNA Amplification With Microfabricated Reaction Chamber", Transducers '93, Jun. 1993.

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