Silicon and sulfur steroids as irreversible inhibitors of hormon

Details Silicon and sulfur steroids as irreversible inhibitors of hormon Silicon and sulfur steroids as irreversible inhibitors of hormon

1983-11-10

1985-12-24

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

2603972, A61K 3156

Patent

active

045605572

ABSTRACT:
The compounds of the present invention are irreversible and highly selective inhibitors of the cytochrome P-450 cholesterol side chain cleavage (P-450scc) enzyme responsible for the first and rate limiting step of steroid hormone biosynthesis by the adrenal glands.

REFERENCES:
Chem. Abstracts, vol. 100, No. 11, Par. 81879(b) (1984).
Chem. Abstracts, vol. 96, No. 23, Par. 198,662(a).
CA-vol. 96, No. 23, Par. 198,662(r), Journ. Org. Chem., 1982, vol. 47, pp. 1983-1984, by Wilson et al. _

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