Silica mediated synthesis of peptides

Details Silica mediated synthesis of peptides Silica mediated synthesis of peptides

1994-05-20

1996-01-23

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

20415782, 502232, 502233, 530339, 562561, B01J 2106, C07K 102, C07K 110

Patent

active

054865980

ABSTRACT:
A method for synthesizing polypeptides from amino acids and/or peptides utilizing a novel reaction medium containing a hydrated silica entity containing silanol groups which function as an inorganic enzyme.

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patent: 5229096 (1993-07-01), Cohen
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Bioceramics, vol. 5, "Reaction Kinetics of Bioactive Ceramics Part V: Molecular Orbital Modeling of Bioactive Glass Surface Reactions," West et al, pp. 75-86 (1992).
Biocermaics, vol. 6, "The Kinetics of Bioactive Ceramics Part VI: Silica-Water-Amino Acid Interactions," Hench et al, pp. 35-40 (1993).
Journal of Non-Crystalline Solids, vol. 152, "Interactions of water with trisiloxane rings. I. Experimental analysis," Wallace et al, pp. 101-108 (1993).
Journal of Non-Crystalline Solids, vol. 152, "Interactions of water with trisiloxane rings. II. Theoretical analysis," West et al, pp. 109-117 (1993).
Journal of Biomedical Materials Research, vol. 28, No. 5, "AM-1 molecular orbital calculations of silica-alanine-nitrogen interaction," West et al, pp. 625-633 (1994).

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