Silanol enzyme inhibitors

Details Silanol enzyme inhibitors Silanol enzyme inhibitors

2006-08-08

2006-08-08

Lukton, David (Department: 1654)

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C556S411000, C556S418000, C556S419000, C556S425000, C556S436000, C562S553000, C514S063000

Reexamination Certificate

active

07087776

ABSTRACT:
Compounds of formula (I, II, or III), wherein X is OH; Y is OH, H, lower alkyl of one to six carbons or heteroatoms or F; Z and Z′ are independently H, lower alkyl or Q3Si where Q is lower alkyl or aryl; n is 3–50; n′ is 2–50; A and B are independently a) alkyl of one to ten carbons or heteroatoms, b) aryl of four to ten carbons or heteroatoms, c) cyclic of three to ten carbons or heteroatoms, or moieties of the formulas (d, e, or f); R1–R11groups are each independently hydrogen, alkyl of one to ten carbons or heteroatoms, aryl of 4 to 14 carbons or heteroatoms, arylalkyl of five to twenty carbons or heteroatoms; unsubstituted carbonyl or substituted carbonyl. Heteroatoms are nitrogen, oxygen, silicon or sulfur. At least one of A or B, or both A and B are d), e), or f). The compounds of formula (I) inhibit protease enzymes and can be used as pharmaceuticals.

REFERENCES:
patent: 5142056 (1992-08-01), Kempe et al.
patent: 5545750 (1996-08-01), Kempf et al.
patent: 6887677 (2005-05-01), Taylor et al.
patent: 6951731 (2005-10-01), Northrop
patent: 0 402 646 (1990-12-01), None

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