Silanol enzyme inhibitors

Details Silanol enzyme inhibitors Silanol enzyme inhibitors

1996-07-12

1998-06-02

Ketter, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

435212, 556424, 556436, 556465, 556487, C12N 900, A01N 5510

Patent

active

057600198

ABSTRACT:
Compounds of formula I ##STR1## in which X is OH

REFERENCES:
patent: 3860709 (1975-01-01), Abbott et al.
patent: 4328216 (1982-05-01), Toyoshima et al.
patent: 4420475 (1983-12-01), Damon, II
patent: 4898977 (1990-02-01), Herold et al.
patent: 4927952 (1990-05-01), Gueyne et al.
patent: 4985405 (1991-01-01), Gueyne et al.
patent: 5037803 (1991-08-01), Gueyne et al.
patent: 5045537 (1991-09-01), Weidmann
patent: 5087452 (1992-02-01), Gueyne et al.
patent: 5215968 (1993-06-01), Nickel et al.
patent: 5401722 (1995-03-01), Juraszyk et al.
Kam, C.M., Nishino, N., Powers, J.C. "Inhibition of Thermolysin and Carboxpeptides A by Phosphoramidates". Biochemistry 1979, 18, 3032-3038.
Amiri, P., Lindquist, R.N., Matteson, D.S., Sadhu, K.M. "Benzamidomethaneboronic Acid: Synthesis and Inhibition of Chymotrypsin". Arch. Biochem Biophys. 1984, 234,531-536.
Galardy, P.E., Kortylewicz, Z.P., "Inhibitors of Angiotensin-Converting Enzyme Containing a Tetrahedral Arsenic Atom", Biochem. J., 1985, 226, 447-454.
Likiess, P.D., "The Synthesis and Structure of Organosilanols," Adv. Inorg. Chem. 1995, 42, 147-262.
Freidberg, K.D., Schiller, E. Handbook on the Toxicity of Inorganic Compounds, Seiler, H.G. and Sigel, H., Eds, Marcel Dekker, New York, 1988, pp. 595-617.
Schechter, I., Berger, A. "On the Active Site of Protease. III. Mapping The Active Site of Papain; Specific Peptide Inhibitors of Papain." Biochem. Biophys. Res Commun. 1968, 32, 898-902.
Schechter, I., Berger, A. "On the size of the Active Site in Proteases. I. Papain", Biochem. Biophys. Res Commun. 1967, 27, 157-162.
I. Fleming, "Organic Silicon Chemistry" in Comprehensive Organic Chemistry, D. Barton, W.D. Ollis, Eds, Pergamon, New York 1979, vol. 3, pp. 576-579.
I. Ojima, "The Hydrosilation Reaction" in The Chemistry of Organic Silicon Compounds, S. Patai and Z. Rappoport, Eds., Wiley, New York 1989, vol. 2, pp. 1479-1525.
Murai, T., Oda, T.,Kimura, F., Onishi, H., T. Kanda, Kato, S., "Rhodium (II) Acetate Catalysed Hydrosilation of Enamides and N-Vinylureas Leading to 1-(Trialkylsilyl) alkylamine Derivatives", J. Chem. Soc. Chem. Commun. 1994, 2143-2144.
Beak, P., Zajdel, W.J., Reitz, D.B. "Metalation Electrophilic Substitution of Amine Derivatives Adjacent to Nitrogen: .alpha.-Metallo Amine Synthetic Equivalents", Chem. Rev. 1984, 84, 471-523.
Eaborn, C., "Cleavages of Aryl-Silicon and Related Bonds by Electrophiles", J. Organomet. Chem. 1975, 100, 43-57.
DeVoss, J.J., Z. Sui, D. DeCamp, R. Salto, L. Babe, C. Craik, P. Ortiz de Montellano "Haloperidol-Based Irreversible Inhibitors of the HIV-1 and HIV-2 Proteases", J. Med. Chem. 1994, 37, 665-673.
Vacca, J.P., "Design of Tight-Binding Hman Immunodeficiency Virus Type 1 Protease Inhibitors", Methods Enzymol. 1994, 2241, 311-334.
Matthews, B.W., "Structural Basis of the Action of Thermolysin And Related Zinc Peptidases", Acc. Chem. Res. 1988, 21, 333-340.
Christianson, D.W., Lipscomb, W.N., "Carboxypeptidase A", Acc. Chem. Res. 1989, 22, 62-69.
Rich, D.H., "Peptidase Inhibitors", in Comprehensive Medicinal Chemistry, C. Hansh et al, Ed., Pegamon, New York 1990, pp. 391-441.
Fischer, G., "Trends in Protease Inhibition" National Product Reports 1988, 5, 465-495.
Gordon, E.M., S. Natarajan, J. Pluscec, H.N. Weller, J.D. Godfrey, M.B. Rom, E.F. Sabo, J. Engebrecht, D.W. Cushman, "Ketomethyldipeptides II. Effect of Modification of the .alpha.-Aminoketone Portion on Inhibition of Angiotensin Converting Enzyme", Biochem. Biophys. Res. Comm. 1984, 124, 148-155.
Bone, R., Sampson, N.S., Bartlet, P.A., Agard, D.A. "Crystal Structure of .alpha.-Lytic Protease Complexes With Irreversibly Bound Phosphonate Esters", Biochemistry 1991, 30, 2263-2272.
Govardhan, C.P., "Structure Activity Studies of Fluroketon Inhibitors Abeles, R.H., of .alpha.-Lytic Protease and Human Leucocyte Elastase", Arch. Biochem Biophys. 1990, 280, 137-146.
Corriu, R.J.P., Guerin, C., Moreau, J.J.E., "Stereochemistry at Silicon", Topics In Sterochemistry 1984, 15, 80-103.
Fisher, J.F., Tarpley, W.G., Thaisrivongs, S., "HIV Protease Inhibitors", in Design of Enzyme Inhibitors As Drugs, M. Sandler and H.J. Smith, Eds, Oxford University Press, New York 1994, vol. 2, pp. 226-229, 251-289.
R. Tacke, D. Reichel, M. Kropfgans, P.G. Jones E. Mutschler, J. Gross, X. Hou, M. Waelbroeck, G. Lambrecht, "Biological Recognition of Enantiomeric Silanes: Syntheses And Antimuscarinic Properties of Optically Active (.alpha.-Aminoethyl)clyclohexl(hydroxy methyl) phenylsilanes And Related Quaternary Ammonium Derivatives", Organometallics 1995, 14, 251-257.
F. Liebner, U. Bankwitz, Ruhlmann, K., Synthese Von Fungicid Wirkamen (1H-.alpha.-, 4-Triazol-1-yl-methyl) silanen Und - siloxanen, Liebigs Ann. Chem. 1994, 145-150.
S. Thaisrivongs, "HIV Protease Inhibitors", Annual Reports In Medicinal Chemistry, ed. J.A. Bristol, Academic Press, Inc., New York 1994, 29, 133-144.
R. Bone, J.P. Vacca, P.S. Anderson, M.K. Holloway, "X-Ray Crystal Structure of the HIV Protease Complex with L-700, 417, An Inhibitor With Pseudo C.sub.2 Symmetry", Journal of the American Chemical Society, 1991, 113, 9382-9384.
J.P. Vacca, J.P. Guare, S.J. deSolms, W.M. Sanders, E.A. Giuliani, S.D. Young, P.L. Darke, J. Zugay, I.S. Sigal, W.A. Schleif, J.C. Quintero, E.A. Emini, P.S. Anderson, J.R. Huff, "Benzocycloalkyl Amines As Novel C-Termini For Hiv Protease Inhibitors", Journal of Medicinal Chemistry, 1991, 34, 228-1230.
I. Fleming, "the Electrophilic Substitution of Allsilanes And Vinylsilanes", Organic Reactions, John Wiley & Sons, Inc., New York, 1989, 61.
J.Y. Corey, D.M., Kraichely, J.L. Huhmann, J. Braddock-Wilking, "Reactions of H(PhMeSi).sub.3 H With Triflic Acid: Evidence of Rearrangement Processes", Organometallics 1994, 13, 3408-3410.
W. Uhlig, "Zur Darstellung Neuer Organosiliciumpolymere Aus Speziell Substituierten Silyltriflatderivaten", Journal of Organometallic Chemistry 1994, 476, 225-229.
H. Stuger, "Synthese 1,4-disubstitierter Tetrasilane Durch Selektive Spaltung Von Si-Phenyl Bindungen", Journal of Organometallic Chemistry 1992, 433, 11-19.
A.R. Bassindale, T. Stout, "The Synthesis of Functionalized Silytriflats", Journal of Organometallic Chemistry 1984, 271, C1-C3.
C. Eaborn, "Organosilicon Compounds. Part I. The Formation of Alkylidosilanes", Journal of the Chemical Society 1949, 2755-2764.
Tacke, R., Linoh, H., "Bioorganosilicon Chemistry" in The Chemistry of Organic Silicon Compounds, S. Patai and Z. Rappoport, Eds, John Wiley, New York 1989, pp. 1143-1206.
Dain, J.G. et al. Xenobiotica, vol. 25 (9), pp. 951-961 1995.
Sawada, H. et al. Journal of Fluorine Chemistry, vol. 75, pp. 121-129 1995.
Zhdanov, A. et al. Zh. Obshch. Khim. vol. 43(60), pp. 1280-1283 (abstract provided) 1973.

Affiliated with

Also associated with

Rating

Silanol enzyme inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Silanol enzyme inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Silanol enzyme inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1459898