Signalling compounds for use in methods of detecting...

Details Signalling compounds for use in methods of detecting... Signalling compounds for use in methods of detecting...

2005-07-19

2005-07-19

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06919463

ABSTRACT:
Compounds useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula:is reacted with peroxide. Sig is an aromatic or heteroaromatic ring group, B is a boron atom, and R5and R6are independently selected from hydrogen and lower alkyl groups and can be joined together as a straight or branched alkylene chain forming a five or six-membered ring. A detectable product compound of the formula Sig-OH Is produced and detected by measuring color, fluorescence, chemiluminescence, or bioluminescence. The signalling compound itself does not possess the detectable property or does so only to a very weak degree. The compounds can be used for detection in assays for peroxide or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs.

REFERENCES:
patent: 5512451 (1996-04-01), Kricka
Kricka et al., Proc. Of the Int. Symp. on Biolum. And Chemlum, 9th, Woods Hale, Mass, Oct. 4-8, 1996 (1997), Meeting Date 1996, 470-480.
Kricka et al, Talanta, (1997), 44(6), pp. 1073-1079.

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