Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1998-11-19
2000-07-18
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435 71, 435 21, 435331, 435346, 5303881, 53038815, 53038826, C12N 506
Patent
active
060906219
ABSTRACT:
Novel polypeptides called signaling inositol polyphosphate 5-phosphatases are described called SIP-130, SIP-125, and SIP-N. SIP-130 is capable of binding to aPTB domain of SH2 and collagen containing protein (SHC). Also provided are polynucleotide sequences encoding the novel polypeptides, as well as vectors and host cells containing the polynucleotides. Further provided are modulators including agonists and antagonists of the novel polypeptides for use as therapeutics, including antibodies, polypeptides, small molecules, and polynucleotides and methods of using the therapeutics in treatment of diseases associated with abnormal cell growth. Methods of making the polypeptides, polynucleotides, vectors, host cells, antibodies, and small molecules are also provided. Gene delivery vehicles including SIP and SIP activity-modulating polynucleotides are described.
REFERENCES:
patent: 4543439 (1985-09-01), Frackelton et al.
patent: 4946778 (1990-08-01), Ladner et al.
Queen et al. "A Humanized Antibody That Binds to the Interleukin 2 Receptor", Proceedings of the National Academy of Science, vol. 86, (Dec. 1989), pp. 10029-10033.
Kavanaugh W. Michael
Pot David
Williams Lewis T.
Blackburn Robert P.
Chiron Corporation
Morley Kimberlin L.
Robins Roberta L.
Stucker Jeffrey
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