Signal transduction via CD28

Details Signal transduction via CD28 Signal transduction via CD28

1993-09-28

1996-06-11

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530330, C12N 500, C07K 500

Patent

active

055255035

ABSTRACT:
Disclosed are compositions and methods of blocking T cell signal transduction by introducing into a T cell a peptide comprising a PI 3-kinase-binding-sequence which decreases the association of PI 3-kinase with CD28. Also disclosed are compositions and methods of amplifying T cell activation by introducing into a T cell, a plurality of modified T cell surface proteins, the cytoplasmic tail of which comprises a plurality of copies of a PI 3-kinase-binding-sequence.

REFERENCES:
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