Signal transduction protein TAB2

Details Signal transduction protein TAB2 Signal transduction protein TAB2

2006-12-26

2006-12-26

Andres, Janet L. (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S069100, C435S320100, C435S325000, C536S023500, C536S024300, C530S350000

Reexamination Certificate

active

07153664

ABSTRACT:
A novel signal transducer TAB2 which acts as an adapter molecule of TRAF6 and TAK1 and mediates the activation of TAK1 in the signal transduction of IL-1 was isolated. TAB2 induced the activation of NF-κB and JNK by IL-1. The signal transduction by IL-1 was inhibited by inhibiting the signal transduction of TAB2 with the use of a dominant negative mutant of TAB2. A compound inhibiting the signal transduction in TAB2 is useful as an anti-inflammatory drug.

REFERENCES:
patent: 5837819 (1998-11-01), Matsuomoto et al.
patent: 5989862 (1999-11-01), Matsuomoto et al.
patent: 6140042 (2000-10-01), Matsuomoto et al.
patent: 2002/0119525 (2002-08-01), Matsuomoto et al.
patent: 0 803 571 (1997-10-01), None
patent: 10-4976 (1998-01-01), None
Sambrook, J., et al. Molecular Cloning. 1989.
Tan et al. Journal of Drug Targeting, 2003, vol. 10(2), pp. 153-160.
Cao et al., “TRAF6 is a signal transducer for interleukin-1”,Nature383:443-446 (1996).
Hillier et al., “Generation and Analysis of 280,000 Human Expressed Sequence Tags”,Genome Research6:807-828 (1996).
Nagase et al., “Prediction of the Coding Sequences of Unidentified Human Genes. XI. The Complete Sequences of 100 new cDNA Clones from Brain Which Code for Large Proteinsin vitro”, DNA Research5:277-286 (1998).
Ninomiya-Tsuji et al., “The kinase TAK1 can activate the NIK-IkB as well as the MAP kinase cascade in the IL-1 signalling pathway”,Nature398:252-256 (1999).
Takaesu et al., “TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway”,Molecular Cell5:649-658 (2000).
Takaesu et al., “Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway”,Molecular and Cellular Biology21:2475-2484 (2001).
European Search Report dated Feb. 13, 2004.
Ohara et al. EMBL Accession No. AB018276 (1998).
Poustka et al. EMBL Accession No. AL117407 (1999).
Shibuya et al. “TAB1” An Activator of the TAK1 MAPKKK in TGF-β Signal TransductionScience272(5265):1179-1182 (1996).
Takaesu et al. “TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway”Molecular Cell5(4):649-658 (2000).
Shibuya, Functional role for TAB1-TAK1 in TGF-β signaling,Seikagaku71:1205-1212 (1999) (with English translation).

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