Signal mediator protein that induces cellular morphological alte

Details Signal mediator protein that induces cellular morphological alte Signal mediator protein that induces cellular morphological alte

1998-11-19

2000-09-26

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 691, 435 6, 536 231, C07K 100, C12Q 168, C12P 2106, C07H 2100

Patent

active

061244341

ABSTRACT:
An isolated nucleic acid molecule is provided which encodes a mammalian signal mediator protein involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an Internal domain containing several SH2 binding motifs, and a carboxy-terminal effector domain that can induce pseudohyphal budding in yeast. The invention also provides the novel signal mediator protein, and antibodies thereto. These biological molecules are useful as research tools and as diagnostic and therapeutic agents for the identification, detection and regulation of complex signaling events leading to morphological, potentially neoplastic, cellular changes.

REFERENCES:
patent: 5716782 (1998-02-01), Golemis et al.

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