Radiant energy – Luminophor irradiation
Reissue Patent
2007-04-03
2007-04-03
Sugarman, Scott J. (Department: 2873)
Radiant energy
Luminophor irradiation
C250S459100, C356S317000
Reissue Patent
active
10035461
ABSTRACT:
The present invention additionally comprises a method and apparatus for generating and mixing signals for frequency-domain lifetime and spectral fluorometry. The present invention comprises a plurality of signal generators that generate a plurality of signals where the signal generators modulate the amplitude and/or the frequency of the signals. The present invention uses one of these signals to drive an excitation signal that the present invention then directs and transmits at a target mixture, which absorbs the energy from the excitation signal. The property of fluorescence causes the target mixture to emit an emitted signal that the present invention detects with a signal detector. The present invention uses a plurality of mixers to produce a processor reference signal and a data signal. The present invention then uses a processor to compare the processor reference signal with the data signal by analyzing the differences in the phase and the differences in the amplitude between the two signals. The processor then extracts the fluorescence lifetime and fluorescence spectrum of the emitted signal from the phase and amplitude information using a chemometric analysis.
REFERENCES:
patent: 5196709 (1993-03-01), Berndt et al.
Weber, G., Resolution of the Florescence Lifetimes in a Heterogeneous System by Phase and Modulation Measurements, J. Phys. Chem., 85, (1981) pp. 949-953.
Lackowicz, J.R., Analysis of Fluorescence Decay Kinetics from Variable-Frequency Phase Shift and Modulation Data, Biophys. J., 46 (1984) pp. 463-477.
Burdick, D.S. et al., Resolution of Multicomponent Fluorescent Mixtures by Analysis of the Excitation-Emission-Frequency Array, J. Chemometrics, 4 (1990) pp. 15-28.
Chin Robert C.
Cruce Tommy Clay
Hallidy William H.
Hanig Richard
Sugarman Scott J.
Systems & Processes Engineering Corporation
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