Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2006-07-04
2006-07-04
Carlson, Karen Cochrane (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C536S023100
Reexamination Certificate
active
07071295
ABSTRACT:
The invention relates to targeting molecules to subcellular locations. In particular, the invention relates to compositions and methods to target molecules to the sarco(endo)plasmic reticulum (SR). The invention includes uses for polypeptide sequences as a localization signal to target therapeutic and experimental compounds or macromolecules to the SR of eukaryotic cells. The invention also includes nucleotide sequences encoding the polypeptide SR localization signal, allowing it to be incorporated into vectors for delivery of therapeutic or experimental gene products via in vitro or in vivo gene transfer.
REFERENCES:
Kimura et al. 1997; J. Biol. Chem. 272(24): 15061-15064.
Kimura et al. 1996; J. Biol. Chem. 271(36): 21726-21731.
Haghighi et al. 2001; J. Biol. Chem. 276(26): 24145-24152.
Ji, Yong, et al., Targeted Inhibition of Ca2+/Calmodulin-Dependent Protein Kinase II in Cardiac Longitudinal Sarcoplasmic Reticulum Results in Decreased Phospholamban Phosphorylation at Threonine 17, The Journal of Biological Chemistry, vol. 278, No. 27, Jul. 4, 2003, pp. 25063-25071, http://www.jbc.org.
Kimura, Y., et al., Phospholamban Domain I/Cytochromeb5Transmembrane Sequence Chimeras Do Not Inhibit SERCA2a, FEBS Letters 425 (1998) pp. 509-512.
Kimura, Y., et al., Phospholamban Inhibitory Function Is Activated By Depolymerization, The Journal of Biological Chemistry, 1997, vol. 272, No. 24, Issue of Jun. 13, pp. 15061-15064.
Kimura, Y., et al., Phospholamban Regulates the Ca2+-ATPase through Intramembrane Interactions, The Journal of Biological Chemistry, 1996, vol. 271, No. 36, Issue of Sep. 6, pp. 21726-21731.
Carlson Karen Cochrane
Hasse & Nesbitt LLC
Intrexon Corporation
Nesbitt Daniel F.
LandOfFree
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