Sigma receptor ligands and the use thereof

Details Sigma receptor ligands and the use thereof Sigma receptor ligands and the use thereof

1992-06-10

2000-05-02

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514651, 514652, 514653, 514654, 514655, 564342, 564344, 564345, 564347, 564348, 564352, 564353, 564354, 564355, 564360, 564361, 564366, 564373, 564378, 564381, 564382, 564383, A01N 3302, C07C21300, C07C21100

Patent

active

060573716

ABSTRACT:
The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT.sub.1A receptors.

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