Sigma binding site agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514212, 5142282, 5142335, 514255, 514318, 514324, 514337, 514422, 514432, 514456, 540596, 544 62, 544151, 544145, 544376, 546193, 546196, 546202, 546269, 546274, 548525, 549 23, 549400, 549401, C07D40112, C07D41312, C07D41712, C07D40312, A61K 31445, A61K 3154, A61K 3155, A61K 3140

Patent

active

052781747

ABSTRACT:
Sigma binding site agents having the formula ##STR1## which are useful to inhibit sigma binding site-induced activity, pharmaceutical compositions including these agents, and methods of using these agents to inhibit sigma binding site-induced activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented agents.

REFERENCES:
patent: 3810896 (1974-05-01), Witte et al.
patent: 3835175 (1974-09-01), Carpino et al.
patent: 3906031 (1975-09-01), Carpino et al.
patent: 4376123 (1983-04-01), Hausberg et al.
patent: 4394519 (1983-07-01), Carpino et al.
patent: 4678787 (1987-07-01), Jaeu
patent: 4780478 (1988-10-01), Hausberg et al.
patent: 4797498 (1989-01-01), Albrecht et al.
patent: 4900727 (1990-02-01), Kattige et al.
Ji et al. "Synthesis of isoflavones as cardiovascular drugs" Yaoxue Xuebao 24 906-12 (1989).
Razdan et al. "Substituted 4-chromanones" CA 79:126312 (1973).
Wu et al. "Flavones 2. Synthesis and Structure-Activity Relationship" J. Med. Chem 32 183-192 (1989).
Hackh's Dictionary p. 27 Fourth Edition (1972).
Jesthi, P. K. et al., J. Indian Chem. Society (1965) vol. 42, pp. 105-108.
Chouinard, G. and Annable, L., Psychopharmacol. (1984), vol. 84, pp. 282-284.
Klosa, V. J., J. Park. Chem. (1963), vol. 22, p. 359.
Bayer, E. and Kramer, B., Chem. Ber. (1964), vol. 97, pp. 1057-1068.
Szegi, J. et al., Congr. Hung. Pharmacol. Soc. [Proc.] (1971), p. 221.
Hetenyi, E. L. et al., Acta Pharm. Hung. (1974), vol. 44, p. 1.
Da Re et al., J. Med. Chem. (1972), vol. 15, No. 8, pp. 868-869.
Briggs, M. T. et al., J. Chem. Res. Synop. (1982), p. 242.
Chem. Abstracts, 99:139772 (1983).
Chem. Abstracts, 94:65430 (1981).
Chem. Abstracts, 63:9918c-9921d. (1965).
Chem. Abstracts, 104:50791 (1986).
Martin, W. R. et al., J. Pharm. Exp. Ther., vol. 197, No. 3 (1976), pp. 517-532.
Chem. Abs., vol. 60, No. 5441d, 1963 (Feb. 17, 1964).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Sigma binding site agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sigma binding site agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sigma binding site agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1631566

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.