SIGIRR DNA and polypeptides

Details SIGIRR DNA and polypeptides SIGIRR DNA and polypeptides

2006-03-07

2008-11-04

Bunner, Bridget E. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S069500, C435S320100, C435S471000, C435S325000

Reexamination Certificate

active

07446171

ABSTRACT:
DNA encoding SIGIRR polypeptides and methods for using the encoded polypeptides are disclosed.

REFERENCES:
patent: WO-9623067 (1996-08-01), None
Wald et al. 2003. Nature Immunology, vol. 4, pp. 920-927.
Luke AJ O'Neill. 2003. Nature Immunology, vol. 4, pp. 823-824.
Mantovani et a1. 2004. . Journal of Leukocyte. Biol. vol. 75, No. 5, pp. 738-742.
Deng et al., Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas, Science 274:2057-2059 (1996).
Dower et al., Interleukin-1 receptors, Biomembranes, 6:147-175 (1996).
GenBank accession No. R88163, Soares adult brain N2b4HB55YHomo sapienscDNA clone, Aug. 16, 1995.
Mantovani et al., Extracellular and intracellular decoys in the tuning of inflammatory cytokines and Toll-like receptors: the new entry TIR8/SIGIRR, J. Leukoc. Biol., 75(5):738-742 (2004) (abstract only).
Nucleotide sequence database EMBL, Accession No. AA490809, Jul. 3, 1997, XP002104579.
O'Neill, SIGIRR puts the brakes on toll-like receptors, Nat. Immunol., 4(9):823-824 (2003).
Polentarutti et al., Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR, Eur. Cytokine Network, 14(4):211-218 (2003) (abstract only).
Thomassen et al., Identification and Characterization of SIGIRR, a molecule representing a novel subtype of the IL-R1 superfamily, Cytokine, 11(6):389-399 (1999).
Wald et al., SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling, Nat. Immunol., 4(9):920-927 (2003).
Qin et al., SIGIRR Inhibits Interleukin-1 Receptor- and Toll-like Receptor 4-mediated Signaling through Different Mechanisms, The Journal of Biological Chemistry, 280(26):25233-25241 (2005).
Heguy et al., Amino Acids Conserved in Interleukin-1 Receptors (IL-1Rs) and theDrosophilaToll Protein are Essential for IL-1R Signal Transduction, The Journal of Biological Chemistry, 267(4):2605-2609 (1992).
Mitcham et al., T1/ST2 Signaling Establishes it as a Member of an Expanding Interleukin-1 Receptor Family, The Journal of Biological Chemistry 271(10):5777-5783 (1996).
Gay et al., “Drosophila Toll and IL-1 receptor” Nature 351:355-356 (1991).

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