Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1991-09-19
1993-03-09
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
435280, 435803, 435852, 562564, A01N 3718
Patent
active
051928078
ABSTRACT:
Antiparasitic agents constituted by a siderophore substance including at least one hydroxamate group, at least one peptide bond, and having a molecular weight of less than 1,000 D, e.g. aerobactin. A method of isolating antiparasitic agents by purification from the supernatant of a culture of an appropriate bacteria such as pathogenic enterobacteria applicable as antiparasitic agents, in particular as antimalarial agents.
REFERENCES:
patent: 4600691 (1986-07-01), Chaiet et al.
Pierre et al. Ann. Pharma. Francaises, 44, p. 255, 1986.
Favier et al. Ann. Pharma. Francaises, 44, p. 329, 1986.
Nassif et al. Infec. & Immunity, 54, p. 603, 1986.
Scheibel et al. Mol. Pharmacol. 30, p. 364 (1986).
J. Clin. Microbiol., vol. 25, pp. 378-379 (1987).
Journal of Medicinal Chemistry, vol. 15, No. 11, 1972, J. B. Hynes et al.: "Hydroxylamine derivatives as potential antimalarial agents. 2. Hydroxamates and amidoximes", pp. 1194-1195.
Breton Catherine
Crenn Yves
Gysin Jurg
Pereira da Silva Luiz
Institut Pasteur
Kishore G. S.
Page Thurman K.
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