Side chain unsaturated 1.alpha.-hydroxyvitanim D homologs

Details Side chain unsaturated 1.alpha.-hydroxyvitanim D homologs Side chain unsaturated 1.alpha.-hydroxyvitanim D homologs

1990-02-14

1993-10-05

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, A61K 3159, C07J17200, C07J17500

Patent

active

052505235

ABSTRACT:
This invention provides novel vitamin D-related compounds characterized by extended unsaturated side chain structures. Such compounds exhibit increased activity in arresting the proliferation and promoting the differentiation of malignant cells with only minimal calcemic activity and thus represents new therapeutic agents applicable and uniquely useful in differentiation therapy of malignant diseases. The activity characteristics of these compounds provide the basis of a method for the treatment of neoplastic diseases, specifically leukemoid diseases.

REFERENCES:
patent: 4391802 (1983-04-01), Suda et al.
patent: 4689180 (1987-08-01), DeLuca et al.
patent: 4717721 (1988-05-01), DeLuca et al.
patent: 4851401 (1989-07-01), DeLuca et al.
patent: 4927815 (1990-05-01), DeLuca et al.
CA 113: 78822r, Calverley et al.
Perlman et al., Biochemistry, 29(1), pp. 190-196 (1990).

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