Side-chain homologous vitamin D derivatives, process for their p

Details Side-chain homologous vitamin D derivatives, process for their p Side-chain homologous vitamin D derivatives, process for their p

1993-06-01

1996-07-02

Prior, Kimberly J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

552653, 540200, 540202, 544 2, 544 3, 544 63, 544224, 546 1, 548100, 548122, 548123, 548124, 548125, 548400, 549 1, 549 13, 549 29, 549 88, A61K 3159, C07C40100

Patent

active

055322280

ABSTRACT:
The invention discloses side-chain homologous vitamin D derivatives of formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, B, and D have the meanings defined in the specification and either (1) A is a direct bond between carbon atoms 20 and 22 and X is an oxy alkylene radical, --(CH.sub.2).sub.n O-- where n is 1 to 3; (2) A is a methylene bridge, --CH.sub.2 --, between carbon atoms 20 and 22 and X is either an alkylene radical, --(CH.sub.2).sub.n -- or an oxy alkylene radical, --(CH.sub.2).sub.n O--, where n is 1 to 3; or (3) if A is a direct bond and B and D together form a second bond, then X(R.sup.5) (R.sup.6) is ##STR2## The compounds possess proliferation-inhibiting and cell-differentiating activity.

REFERENCES:
patent: 4267117 (1981-05-01), Salmond

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