Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-03-30
1994-02-01
Raymond, Richard L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
436501, 530409, 544355, 546 61, 546 79, 546 93, 546102, 546107, 546108, 546112, 546147, 546170, 5483094, C07D21904
Patent
active
052833348
ABSTRACT:
A chemiluminescent compound possessing an aryl ester, thioester or amide of a carboxylic acid substituted heterocyclic ring or ring system that is susceptible to chemical attack to dissociate the heterocyclic ring to a transient compound. The heterocyclic ring is ring carbon-bonded to the carbonyl of the ester, thioester or amide moiety and possesses a heteroatom in an oxidation state that allows chemiluminescence by dissociating a compound at the carbon bonded to the carbonyl that decays to produce chemiluminescence. The heterocyclic ring or ring sustem contains bonded to it through an organic moiety, a functional group that is functionally reactive with an active hydrogen containing compound. The aryl ring is a ring or ring system that is ring carbon-bonded to the oxygen, sulfur or nitrogen of the ester, thioester or amide, as the case may be, and contains substituents on a six-member ring that act to sterically and electronically hinder hydrolysis of the ester, thioester or amide linkage. Optionally, there is an electron donating substituent in a peri position on the heterocyclic ring system. The substituents on the aryl ring comprise at least one ortho electron donating substitution that with the peri substitution comprises at least two substituents adjacent to the ester, thioester or amide linkage that are electron donors; at least one meta or para substituent on the aryl ring that possesses a .sigma..sub.p value greater than 0 and less than 1.
Also described are assays and assay kits that employ such label compounds.
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London Diagnostics, Inc.
Raymond Richard L.
Skoler George A.
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