Sialyl Lewis X mimetics incorporating mannopeptides

Details Sialyl Lewis X mimetics incorporating mannopeptides Sialyl Lewis X mimetics incorporating mannopeptides

1996-12-12

1998-11-17

Fonda, Kathleen K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 23, 514 53, 530322, C07H 702, C07H 706, A61K 3170

Patent

active

058378626

ABSTRACT:
Sialyl Lewis X mimetics based on mannose glycosides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The mannose based mimetics exhibit comparable biological activity as sialyl Lewis X in the E- selectin binding assay and can be employed for blocking neutrophil inflamatory conditions.

REFERENCES:
patent: 5591882 (1997-01-01), Erbe et al.
patent: 5618785 (1997-04-01), Heavner et al.
Dupre et al. Bioorganic & Medicinal Chemistry letters March 5, 1996, 6(5), 569-572.

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