Sialyl Lewis X mimetics incorporating fucopeptides

Details Sialyl Lewis X mimetics incorporating fucopeptides Sialyl Lewis X mimetics incorporating fucopeptides

1997-09-19

1999-10-05

Tsang, Cecilia J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 187, 514 23, 530322, 548535, C07H 1500

Patent

active

059626607

ABSTRACT:
Sialyl Lewis X mimetics incorporating fucopeptides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The fucopeptides exhibit substantially the same biological activity as sialyl Lewis X in the E-selectin binding assay and can be employed for blocking neutrophil inflamatory conditions.

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