Sialyl Le.sup.x analogues as inhibitors of cellular adhesion

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 172, 536124, A61K 3170, C07H 1500

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active

058542183

ABSTRACT:
The present invention relates to analogues of sialyl Le.sup.x that inhibit cellular adhesion between a selectin and cells that express sialyl Le.sup.x on their surfaces, as well as methods and compositions using the same, intermediates and methods for the preparation of the cellular adhesion inhibitor compounds and their intermediates. A contemplated intermediate or inhibitor compound has a structure that corresponds to that of Formula A, ##STR1##

REFERENCES:
patent: 4324663 (1982-04-01), Lowe
patent: 5079353 (1992-01-01), Ratcliffe et al.
patent: 5143712 (1992-09-01), Brandley et al.
patent: 5211936 (1993-05-01), Brandley et al.
patent: 5211937 (1993-05-01), Brandley et al.
patent: 5296594 (1994-03-01), Ratcliffe et al.
patent: 5352670 (1994-10-01), Venot et al.
patent: 5576305 (1996-11-01), Ratcliffe
Danishefsky, Samuel J., et al. (1995) "Application of Glycals to the Syntheses of Oligosaccharides: Convergent Total Synthesis of the Lewis X Trisaccharide Sialyl Lewis X Antigenic Dterminant and Higher Congeners", J. Am. Chem. Soc., 117:1940-1953.
DeFrees, Shawn A., et al. (1996) "Sialyl Lewis x Lipsomes as a Multivalent Ligand and Inhibitor of E-Selectin Mediated Cellular Adhesion", J. Am. Chem. Soc., 118:6101-6104.
Graber et al., J. Immunol., 145:819 (1990).
Bevilacqua et al. Science, 243:1160-1165 (1989).
Hession et al., Proc. Natil. Acad. Sci., 87:1673-1677 (1990).
Bevilacqua et al., Proc. Natl. Acad. Sci., 84:9238-9242 (1987).
Lasky et al., Cell, 56:1045-1055 (1989).
Drickamer, J. Biol. Chem., 263:9557-9560 (1988).
Springer, Nature, 346:425-434 (1990).
Nelson et al., J. Clin. Invest., 91:1157-1166 (1993).
Furui et al., Carbohydrate Res., 229:C1-C4 (1992).
Siegelman et al., Science, 243:1165-1172 (1989).
Langer, Science, 249:1527-1533 (1990).
Green et al. Biochem. Bilophys. Res. Commun., Oct. 15, 1992, 188(1), 244-251.
Needham et al. Proc. Nat. Acad. Sci. USA Feb. 1993, 90, 1359-1363.
DeFrees et al., J. Am. Chem. Soc., Aug. 11, 1993, 115(16), 7549-7550.
Zhou et al., J. Cell Biol. 1991, 115(2), 557-563.
Danishefsky et al., J. Am Chem. Soc.4 1992, 114(2), 8331-8333.
Tyrrell, et al. (1991) "Structural requirements for the carbohydrate ligand of E-selectin", Proceedings of the National Academy of Sciences, 88:10372-10376.
AK Phillips, et al. (1990) "Elam-1 mediates cell adhesion by recognition of a carbohydrate ligand, Sialyl-Le.sup.x ", Science, 250:1130-1131.
AL Walz, et al. (1990) "Recognition by ELAM-1 of Sialyl-Le.sup.x determinant on myeloid and tumor cells", Science, 250:1132-1135.
Am Munro, et al. (1992) "Expression of Sialyl-Lewis X, an E-selectin ligand, in inflammation, immune processes, and lymphoid tissues",American Journal of Pathology, 141(6);1397-1408.
An Ball, et al. (1991) "Structural requirements for the carbohydrate ligand of E-selectin", Proceedings of the National Academy of Sciences, 88:10372-10376.

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