Sialic acid glycosides, antigens, immunoadsorbents, and methods

Details Sialic acid glycosides, antigens, immunoadsorbents, and methods Sialic acid glycosides, antigens, immunoadsorbents, and methods

1990-06-28

1994-03-22

Saunders, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 723, 435 79, 435188, 436543, 436544, 530403, 530413, 536 182, C07H 506, C07K 320, G01N 33531

Patent

active

052965945

ABSTRACT:
The stereochemistry of sialylation of an acceptor saccharide to obtain an .alpha. (2-3) or .alpha. (2-6) linkage is controlled to favor the a anomer by use of an aromatic ester of the sialyl reagent. The resulting intermediate .alpha. (2-3) and .alpha. (2-6) sialylated intermediate disaccharide blocks are useful in the synthesis of antigenic substances which can be used to raise antibodies useful in diagnosis and therapy, and can themselves be used as reagents in various applications. The preparation of the tetrasaccharide antigens corresponding to the 19-9 and sialyl-X antigens characteristic of malignant tissue illustrates the application of this method.

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