Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2004-08-12
2010-10-05
Olson, Eric S (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S123100, C514S054000
Reexamination Certificate
active
07807824
ABSTRACT:
Derivatives are synthesised of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal unit is transformed into an aldehyde group. Where the polysaccharide has a sialic acid unit at the non-reducing end it may be passivated, for instance by converting into hydroxyl-substituted moiety. The derivatives may be reacted with substrates, for instance containing amine or hydrazine groups, to form non-cross-linked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs peptides or proteins or drug delivery systems.
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Gregoriadis Gregory
Hreczuk-Hirst Dale Howard
Jain Sanjay
Laing Peter
Papaioannou Ioannis
Lipoxen Technologies Limited
Morrison & Foerster / LLP
Olson Eric S
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