Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-12-23
1998-01-27
Prior, Kimberly J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514172, 536 291, 549417, A61K 3170, A61K 3158, C07D31500
Patent
active
057122547
ABSTRACT:
Sialic acid derivatives represented by the general formula (I): ##STR1## wherein R.sup.1 is a steroidal compound residue; R.sup.2 is H or alkyl;
R.sup.3 is alkyl; ##STR2## wherein each of R.sup.6 and R.sup.7 is H, alkyl or the like and I is an integer of 0 to 6; or the like;
X is O or S;
R.sup.4 is H or acyl; and R.sup.5 is R.sup.14 O-- (R.sup.14 is H or acyl) or R.sup.15 NH--(R.sup.15 is acyl or the like);
their salts, hydrates or solvates are provided.
Sialic acid derivatives of the present invention are expected to be effective medicines for the prevention and therapy of senile dementia including Alzheimer's disease and the like, because they increase ChAT activity in cholinergic neurons.
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Ando Naoko
Chaki Haruyuki
Morinaka Yasuhiro
Saito Ken-Ichi
Yoshida Rie
Mitsubishi Chemical Corporation
Prior Kimberly J.
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