Sialic acid-bonded octapeptide and preparation thereof

Details Sialic acid-bonded octapeptide and preparation thereof Sialic acid-bonded octapeptide and preparation thereof

1989-06-28

1990-10-16

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Peptides containing saccharide radicals, e.g., bleomycins, etc.

530328, 530333, 530335, 530337, 530343, C07K 706, C07K 900

Patent

active

049636537

ABSTRACT:
A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

REFERENCES:
patent: 4694076 (1987-09-01), Ogawa et al.
patent: 4797477 (1989-01-01), Yoshimura et al.

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