Sia.alpha. 2,3Gal.beta. 1,4GlcNAc .alpha. 2,8-sialyltransferase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

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536 232, C12N 910, C12N 1554

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057982449

ABSTRACT:
The subject invention provides Sia.alpha.2,3 Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransferase and an enzymatically active fragment thereof, and a nucleotide sequence encoding said sialyltransferase. The subject invention also provides an extracellularly releasable protein capable of catalyzing Sia.alpha.2,3Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransfer which comprises the enzymatically active fragment of the Sia.alpha.2,3Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransferase together with a signal peptide.

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