Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-01-11
2011-01-11
Padmanabhan, Sreenivasan (Department: 1628)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S404000
Reexamination Certificate
active
07868185
ABSTRACT:
The present invention relates to small molecule protein tyrosine phosphatase inhibitors, especially Shp-2 inhibitors, of formula (I) and/or (II), and to pharmaceutical compositions comprising them. The invention is also directed to the use of said compounds for the treatment of phosphatase-mediated diseases, especially cancer and metastasis. The invention further concerns a method for treating a proliferative disease, a genetic disorder, an autoimmune disease, an angiogenic disorder or cancer in a patient in need of such treatment, comprising administering to said patient a therapeutically effective amount of at least one compound of formula (I) and/or (II).
REFERENCES:
Vippagunta et al.; “Crystalline solids”; 2001; Advanced Drug Delivery Reviews; 2-26.
Hu, Yunan, et al.; “Identification of Selective Inhibitors for the Glycosyltransferase MurG via High-Throughput Screening”; Chemistry & Biology; 2004; pp. 703-711; vol. 11, No. 5, XP002348827.
Wimmers, Erin, et al.; “Design and synthesis of inhibitors of the protein tyrosine phosphatase, SHP-2”; Peptides for the New Millennium; 2000; pp. 604-605; Kluwer Academic Publishers, XP009055304.
Database Chemcats Online Chemical Abstracts Service, Columbus, Ohio, US, Jan. 1, 2004, “Ambinter Screening Library”, XP002349814.
Database Chemcats Online Chemical Abstracts Service, Columbus, Ohio, US, Sep. 17, 2004, XP002349815.
Database Chemcats Online Chemical Abstracts Service, Columbus, Ohio, US, Mar. 17, 2004, “Synthetic and Natural Compounds Product List”, XP002349816.
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Database Chemcats Online Chemical Abstracts Service, Columbus, Ohio, US, Jan. 18, 2005, “Interchim Intermediates”, XP002349818.
Hu, Yunan, et al.; “Identification of Selective Inhibitors for the Glycosyltransferase MurG via High-Throughput Screening”; Chemistry & Biology; 2004; pp. 703-711; vol. 11, No. 5.
Wimmers, Erin, et al.; “Design and synthesis of inhibitors of the protein tyrosine phosphatase, SHP-2”; Peptides for the New Millennium; 2000; pp. 604-605; Kluwer Academic Publishers.
Birchmeier Walter
Grosskopf Stefanie
Hellmuth Klaus
Rademann Joerg
Forschungsverbund Berlin E, V.
Max-Delbruck-Centrum Fur Molekulare Medizin
Millen White Zelano & Branigan P.C.
Padmanabhan Sreenivasan
Thomas Timothy P
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