Shortened glucagon-like peptide 1(sGLP-1) preparation method...

Details Shortened glucagon-like peptide 1(sGLP-1) preparation method... Shortened glucagon-like peptide 1(sGLP-1) preparation method...

2006-03-30

2010-11-16

Lukton, David (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C530S308000, C514S012200

Reexamination Certificate

active

07834142

ABSTRACT:
This invention relates to similar compound of glucagon-like peptide 1 (glucagon-like peptide-1, GLP-1) secreted by insulinotropic hormone, i.e. shortened glucagon-like peptide 1 (sGLP-1) consisting of 26 aminoacids. Its sequence is as follows: His-X1-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu (SEQ ID NO: 2). In comparison with the present GLP-1 and its similar compound, the shortened glucagon-like peptide 1 (sGLP-1) in this invention has the following prominent advantages: 1. After reconstruction, the shortened peptide chain has stronger simulation to islet cell captors and stronger insulin secretion stimulation action; 2. the reconstructed simulation sequence can resist dipeptidyl peptidase decomposition by change of the second aminoacid sequence from Ala to Gly or Ser to prolong its half time and enhance drug action; 3. To shorten the peptide chain leads to reduced synthesis cost.

REFERENCES:
patent: 6133235 (2000-10-01), Galloway et al.
patent: 6268343 (2001-07-01), Knudsen et al.
patent: 2006005667 (2006-01-01), None
patent: 2006097537 (2006-09-01), None
Li, Yuan, Journal of Peptide Science 14(7), 777-785, 2008.

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