Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1992-07-10
1994-05-31
Hill, Jr., Robert J.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
424 93V, 424 858, 4352402, A61K 3514, A61K 4505, C12N 506
Patent
active
053167635
ABSTRACT:
The present invention is directed to a method of increasing the in vivo immune response of lymphocytes by stimulating the lymphocytes in vitro in the presence of an anti-CD3 monoclonal antibody for less than about 24 hours to form stimulated lymphocytes; infusing the stimulated lymphocytes into a tumor-bearing mammal; and administering IL-2 to the mammal. As a result of this method, the anti-CD3 stimulated lymphocytes display enhanced immunotherapeutic, e.g., cytotoxicity or lymphokine production, in vivo as represented by a decrease in the number of tumors by at least about 20%.
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Loeffler Cynthia
Longo Dan L.
Ochoa Augusto C.
Urba Walter
Fitzgerald David L.
Hill Jr. Robert J.
Regents of the University of Minnesota
The United States of America as represented by the Department of
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