Short polypeptide sequences useful in the production and detecti

Details Short polypeptide sequences useful in the production and detecti Short polypeptide sequences useful in the production and detecti

1988-08-19

1993-02-09

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 424 858, 530326, 530327, 530328, 530329, 530402, 530403, 5303879, 530826, 53038835, 5303872, 514 13, 514 14, 514 15, 514 16, 514 17, 43524027, A61K 3912, A61K 3921, C07K 700

Patent

active

051851474

ABSTRACT:
Polypeptides in the size range 6-11 amino acids from discrete regions of the human immunodeficiency virus p17 protein are immunogenic and form the basis for diagnosis and therapy of HIV-related disease.

REFERENCES:
patent: 4843011 (1989-06-01), Sarngadharan
patent: 4983387 (1991-01-01), Goldstein
H. M. Geysen et al., "Strategies for epitope analysis using peptide synthesis", J. Immunol. Meth., 102, 259-274 (1987).
G. Walter, "Production and use of antibodies against synthetic peptides", J. Immunol. Meth., 88, 149-161 (1986).
R. Jemmerson et al., "Mapping Antigenic Sites on Proteins: Implications for the Design of Synthetic Vaccines", BioTechniques, vol. 4, 18-31 (1986).
T. P. Hopp et al., "Prediction of Protein antigenic determinants from amino acid sequences", Proc. Natl. Acad. Sci., USA, 78, 3824-3828 (1981).
C. L. Parravicini et al., "Monoclonal Antibodies to the Human Immunodeficiency Virus p18 cross-react with normal Human Tissues", AIDS, 2, 171-177 (1988).
P. S. Sarin et al., "Neutralization of HTLV-III/LAV Replication by Antiserum to Thymosin.alpha.", Science, 232, 1135-1137 (1986).
P. H. Naylor et al., "Human immunodeficiency virus contains an epitope immunoreactive with thymosin.alpha., and the 30-amino acid synthetic p17 group-specific antigen peptide HGP-30" Proc. Natl. Acad. Sci., USA, 84, pp. 2951-2955 (1987).
J. Ritter et al., "Lack of reactivity of anti-human immunodeficiency virus (HIV) P17/18 antibodies against .alpha.1 thymosin and of anti-.alpha.1 thymosin monoclonal antibody against P17/18 protein" Immunology Letters, 16, pp. 97-100 (1987).

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