Short bioactive peptides

Details Short bioactive peptides Short bioactive peptides

2005-04-05

2005-04-05

Carlson, Karen Cochrane (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

06875744

ABSTRACT:
Short bioactive peptides containing phenylalanine, leucine, alanine, and lysine residues are disclosed. The peptides can be used in antibacterial, antifungal, anticancer, and other biological applications.

REFERENCES:
patent: 5561107 (1996-10-01), Jaynes et al.
patent: 5620954 (1997-04-01), Maloy
patent: 5717064 (1998-02-01), Julian et al.
patent: 5744445 (1998-04-01), Jaynes et al.
patent: 5861478 (1999-01-01), Jaynes
patent: 5962410 (1999-10-01), Jaynes et al.
patent: 6001805 (1999-12-01), Jaynes et al.
patent: 6084156 (2000-07-01), Garbabino et al.
patent: 6191110 (2001-02-01), Jaynes et al.
patent: 6255282 (2001-07-01), Jaynes
patent: 6303568 (2001-10-01), Jaynes et al.
patent: 6331440 (2001-12-01), Nordstedt et al.
patent: 6440935 (2002-08-01), Jaynes et al.
patent: 6559281 (2003-05-01), Jaynes
patent: 6566334 (2003-05-01), McLaughlin
patent: 6635740 (2003-10-01), Enright et al.
patent: WO 0149834 (2001-07-01), None
Bessalle, et al., “Structure-Function Studies of Amphiphilic Antibacterial Peptides,” J. Med. Chem., 1993, 36:1203-1209.
Oh, J.E., et al., “Design, Synthesis and Characterization—(A Model Decapeptide),” J. Peptide Res., 1999, 54:129-136.
Form PCT/ISA/220 International Search Report dated Oct. 3, 2002.
Zboinska et al. Antibacterial activity of phosphono dipeptides based on 1-amino-1-methylethanephosphonic acid. FEMS Microbiology Letters. 1990. vol. 70, pp. 23-28, especially pp. 23 and 25-27.
Epand et al, “Diversity of antimicrobial peptides and their mechanisms of action,”Biochimica et Bioophysica Acta1462, pp. 11-28 (1999).
Dathe et al, “Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cells,”Biochimica et Biophysica Acta1462, pp. 71-87 (1999).
Jia et al, “Antimicrobial Peptides Protect Coho Salmon fromVibrio anguillarumInfections,”Applied and Environmental Microbiology, vol. 66, No. 5, pp. 1928-1932 (May 2000).
Wang et al, “The effect of pH on the structure, binding and model membrane lysis by cecropin B and analogs,”Biochimica et Biophysica Acta1473, pp. 418-430 (1999).
Osapay et al., “Formation and Characterization of a Single Trp-Trp Cross-link in Indolicidin that Confers Protease Stability without Altering Antimicrobial Activity,”The Journal of Biological Chemistry, vol. 275, No. 16, pp. 12017-12022 (Apr. 21, 2000).
Shin et al, “Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells,”Biochimica et Biophysica Acta1463, pp. 209-218 (2000).
Rocca et al, “Simulation studies of the interaction of antimicrobial peptides and lipid bilayers,”Biochimica et Biophysica Acta1462, pp. 185-200 (1999).
Blondelle et al, “Lipid-induced conformation and lipid-binding properties of cytolytic and antimicrobial peptides: determination and biological specificity,”Biochimica et Biophysica Acta1462, pp. 89-108 (1999).
Giacometti et al, “Antimicrobial activity of polycationic peptides,”Peptides20, pp. 1265-1273 (1999).
Baghian et al, “An Amphipathic α Helical Synthetic Peptide Analogue of Melittin Inhibits Herpes Simples Virus-1 (HSV-1)-Induced Cell Fusion and Virus Spread,”Peptides, vol. 18, No. 2, pp. 177-183 (1997).
Wu et al, “Improved Derivatives of Bactenecin, a Cyclic Dodecameric Antimicrobial Cationic Peptide,”Antimicrobial Agents and Chemotherapy, pp. 1274-1276 (May 1999).
Oh et al, “Activities of Synthetic Hybrid Peptides against Anaerobic Bacteria: Aspects of Methodology and Stability,”Antimicrobial Agents and Chemotherapy, pp. 68-72 (Jan. 2000).
Silvestro, et al, “Antibacterial and Antimembrane Activities of Cecropin A inEscherichia coli,” Antimicrobial Agents and Chemotherapy, pp. 602-607 (Mar. 2000).
Hancock, et al, “Peptide Antibiotics,”Antimicrobial Agents and Chemotherapy, pp. 1317-1323 (Jun. 1999).
Schwab, et al, “In vitro Activities of Designated Antimicrobial Peptides against Multidrug-Resistant Cystic Fibrosis Pathogens,”Antimicrobial Agents and Chemotherapy, pp. 1435-1440 (Jun. 1999).
Friedrich, et al, “Salt-Resistant Alpha-Helical Cationic Antimicrobial Peptides,”Antimicrobial Agents and Chemotherapy, pp. 1542-1548 (Jul. 1999).
Goraya, et al, “Peptides with antimicrobial activity from four different families isolated from the skins of the North American FrogsRana luteiventris, Rana berlandieriandRana pipiens,” Eur. J. Biochem267, pp. 894-900 (2000).
De Lucca et al, “Fungicidal properties, sterol binding, and proteolytic resistance of the synthetic peptide D4E1,”Can. J. Microbiol., 44, pp. 514-520 (1998).
Hong, et al, “Structure and Organization of Hemolytic and Nonhemolytic Diastereomers of Antimicrobial Peptides in Membranes,”Biochemistry, 38, pp. 16963-16973 (1999).
Hung, et al, “Membrane Lysis by the Antibacterial Peptides on Cecropins B1 and B3: A Spin-Label Electron Spin Resonance Study on Phospholipid Bilayers,”Biophysical Journal, vol. 77, pp. 3120-3233 (Dec. 1999).
Robertson, et al, “Peptidyl membrane-interactive molecules are cytotoxic to prostatic cancer cells in vitro,”World J Urol16, pp. 405-409 (1998).
Martin, et al, “Evaluation of the effect of peptidyl membrane-interactive molecules on avian coccidia,”Parasitol Res85, pp. 331-336 (1999).
Giacometti, et al, “In-vitro activity of cationic peptides alone and in combination with clinically used antimicrobial agents againstPseudomonas aeruginosa,” Journal of Antimicrrobial Chemotherapy44, pp. 641-645 (1999).
Oh, et al, “Cationic peptide antimicrobials induce selective transcription of micF and osmY inEscherichia coli,” Biochimica et Biophysica Acta1463, pp. 43-54 (2000).
Scott, et al, “Biological Properties of Structurally Related α-Helical Cationic Antimicrobial Peptides,”Infection and Immunity, vol. 67, No. 4, pp. 2005-2009 (1999).
Scott, et al, “Cutting Edge: Cationic Antimicrobial Peptides Block the Binding of Lipopolysaccharide (LPS) to LPS Binding Protein,”The Journal of Immunology, pp. 549-553 (2000).
Zhang, et al, “Influence of Proline Residues on the Antibacterial and Synergistic Activities of α-Helical Peptides,”Biochemistry38, pp. 8102-8111 (1999).
Wu, et al, “Mechanism of Interaction of Different Classes of Cationic Antimicrobial Peptids with Planar Bilayers and with the Cytoplasmic Membrane ofEscherichia coli,” Biochemistry38, pp. 7235-7242 (1999).
Lowenberger, et al, “Antimicrobial Activity Spectrum, cDNA Cloning, and mRNA Expression of a Newly Isolated Member of the Cecropin Family from the Mosquito VectorAedes aegypti,” The Journal of Biological Chemistry, vol. 274, No. 29, pp. 20092-20097 (1999).
Kondejewski, et al, “Dissociation of Antimicrobial and Hemolytic Activities in Cyclic Peptide Diastereomers by Systematic Alterations in Amphipathicity,”The Journal of Biological Chemistry, vol. 274, No. 19, pp. 13181-13192 (May 7, 1999).
Zhang, et al, “Determinants of Recombinant Production of Antimicrobial Cationic Peptides and Creation of Peptide Variants in Bacteria,”Biochemical and Biophysical Research Communications247, pp. 674-680 (1998).
Hancock, “Host Defence (Cationic) Peptides. What Is Their Future Clinical Potential?”Drugs(4), pp. 469-473 (Apr. 1999).
Shin, et al, “Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-meliittin hybrid peptides.”J. Peptide Res.53, pp. 82-90 (1999).
Juvvadi, et al, “Structure-activity studies of normal and retro pig cecropin-melittin hybrids,”J. Peptide Res.53, pp. 244-251 (1999).
Dushay, et al, “Two attacin antibacterial genes ofDrosophila melanogaster,” Gene246, pp. 49-57 (2000).
Hancock, ȁ

Affiliated with

Also associated with

Rating

Short bioactive peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Short bioactive peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Short bioactive peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3375815