Shiga toxin B chain polypeptides and vaccine thereto

Details Shiga toxin B chain polypeptides and vaccine thereto Shiga toxin B chain polypeptides and vaccine thereto

1989-06-09

1993-04-20

Draper, Garnette

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

530323, 530326, 530327, 530328, 530345, 530402, 530403, 530404, 530405, 530825, 424 88, 527200, 527202, 514 2, 514 13, 514 14, 514 15, A61K 3902, C07K 700, C08H 100

Patent

active

052040976

ABSTRACT:
The invention relates to a number of synthetic polypeptides which correspond to a part of the sequences of the Shiga B peptide chain. More specifically, the invention relates to polypeptides corresponding to the residues 5 to 18, 7 to 26, 13 to 26, and 19 to 29 of said B chain. The invention further relates to the conjugates of each of these with a suitable carrier and to polymers of each or these obtained by polymerization with a suitable polymerization agent: these can be used as effective vaccines which afford protection against Shiga toxin. Anti-peptide anti-sera are effective in neutralizing to a large extent the biological activity of Shiga toxin.

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Bacterial Vaccines and Local Immunity, Nos. 1-2, 1986, pp. 125-130; I. Harari et al; "Synthetic Peptides of Shiga Toxin B-subunit Induce . . . ".
J. Exp. Med., vol. 160, Dec. 1984, pp. 1767-1781, the Rockefeller University Press; A. Donohue-Rolfe et al; "Pathogenisis of Shigella Diarrhea. IX. Simplified High Yield . . . ".

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