Shell-and-core dosage form approaching zero-order drug release

Details Shell-and-core dosage form approaching zero-order drug release Shell-and-core dosage form approaching zero-order drug release

2002-08-07

2010-06-15

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C424S468000, C424S464000, C424S474000, C424S472000

Reexamination Certificate

active

07736667

ABSTRACT:
Drugs are formulated as oral dosage forms for controlled release in which the release rate limiting portion is a shell surrounding the drug-containing core. The shell releases drug from the core by permitting diffusion of the drug from the core. The shell also promotes gastric retention of the dosage form by swelling upon imbibition of gastric fluid to a size that is retained in the stomach during the postprandial or fed mode.

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