Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-02-28
2000-06-20
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 4353201, 4352521, C12P 2106, C12N 112, C12N 1500, C12N 500
Patent
active
060776862
ABSTRACT:
A Shc protein which is characterized as follows: (a) containing a C-terminal Src homology 2 (SH2) domain, a central proline-rich region (CH1), and an N-terminal phosphotyrosine binding (PTB) domain; (b) it is predominantly expressed in the adult brain; (c) it binds through its SH2 domain to proteins containing the consensus sequence pTyr-(hydrophobic/Glu)-(hydrophobic/Met/Tyr/Ile)-(Ile/Leu/Met/Phe/Tyr); and (d) it associates through its PTB domain with proteins containing the consensus sequence Asn-Pro-X-pTyr where X is any amino acid; nucleic acids encoding the protein; and uses of the protein. The Shc proteins mediate signaling from tyrosine kinases in the nervous system.
REFERENCES:
Blaikie, P. et al. "A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors." The Journal of Biological Chemistry (Dec., 1994), vol. 269, No. 51, pp. 32031-32034.
O'Bryan et al., "A Mammalian Adaptor Protein with Conserved Src Homology 2 and Phosphotyrosine-Binding Domains is Related to Shc and is Specifically Expressed in the Brain", Proc. Natl. Acad. Sci., 93(7):2729-2734 (Apr. 2, 1996).
O'Bryan et al., "Binding Specifically and Mutational Analysis of the Phosphotyrosine Binding Domain of the Brain-Specific Adaptor Protein ShcC", J. Biol. Chem., 271(20):11787-11791 (May 17, 1996).
W.M. Kavanaugh et al., "An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins", Science, 266:1862-1865 (Dec. 16, 1994).
W.M. Kavanaugh et al., "PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine", Science, 268:1177-1179 (May 26, 1995).
T. Nakamura et al., "N-Shc: A Neural-Specific Adaptor Molecule that Mediates Signaling from Neurotrophin/Trk to Ras.MAPK Pathway", Oncogene, 13:1111-1121 (Sep. 1996).
Z. Songyang et al., "SH2 Domains Recognize Specific Phosphopeptide Sequences", Cell, 72:767-778 (Mar. 12, 1993).
G. Pelicci et al., "A Family of Shc Related Proteins with Conserved PTB, CH1 and SH2 Regions", Oncogene, 13:663-641 (Aug. 1, 1996).
Cribbs, D.H. et al (1996) Neuroscience 75:173-85.
Di Fiore, P.P. et al (1987) Cell 51:1063-1070.
Di Guglielmo et al (1994) Embo J 13:4269-77.
Giorgetti, S.P. et al (1994) Eur J Biochem 223:195-202.
Hauser, C.A. et al (1995) Meth Enzymol 255:412-26.
Henkemeyer, M.L. et al (1994) Oncogene 9:1001-14.
Marais, R. et al (1993) Cell 73:381-93.
Maru, Y. et al (1990) Oncogene 5:445-447.
Merlino, G.T. et al (1985) Mol. Cell. Biol. 5:1722-1734.
O'Bryan, J.P., et al (1995) J Biol Chem 270:551-7.
O'Bryan, J.P. et al (1991) Mol. Cell. Biol. 11:5016-5031.
Pike, C.J. et al (1994) Neuroscience 63:517-31.
Rameh, L.E. et al (1995) Cell 83:821-830.
Serunian, L.A. et al (1991) Meth Enzymol 198:78-87.
Tanaka, M. and W. Herr (1990) Cell 60:375-86.
Ullrich, A.L. et al (1984) Nature 309:418-425.
van der Geer et al (1996) Proc. Natl. Acad. Sci. USA 93:963-968.
Velu, T.J. et al (1987) Science 238:1408-1410.
Yajnik, V. et al (1996) J. Biol. Chem. 271:1813-1816.
Zhou, M.-M. et al (1995) Nature 378:584-592.
Batzer, A. et al (1994) Mol. Cell. Biol. 14, 5192-5201.
Yokote, K. et al (1994) J Biol Chem 269, 15337-43.
Kavanaugh, W.M. et al (1995) Science 268, 1177-1179.
van der geer, P. et al (1995) Curr Biol 5, 404-412.
Pawson, T. (1995) Nature 373, 573-579.
Burns, L.A. et al (1993) J Biol Chem 268, 17659-61.
Cutler, R.L. et al (1993) J Biol Chem 268, 21463-5.
Damen, J.E. et al (1993) Blood 82, 2296-303.
Lanfrancone, L. et al (1995) Oncogene 10, 907-17.
Ravichandran, K.S. et al (1993) Science 262, 902-905.
Crowe, A.J. et al (1994) Oncogene 9, 537-44.
McGlade, J. et al (1992) Proc. Natl. Acad. Sci. USA 89, 8869-8873.
Salcini, A.E. et al (1994) Oncogene 9, 2827-36.
Rozakis, A.M. et al (1992) Nature 360, 689-92.
Obermeier, A. et al (1993) J. Biol. Chem. 268, 22963-22966.
Stephens, R.M. et al (1994) Neuron 12, 691-705.
Lai, K.-M. et al (1995) Mol Cell Biol. 15:4810-4818.
O'Bryan, J.P. et al (1991) Mol. Cell. Biol. 11, 5016-5031.
Songyang, Z. et al (1993) Cell 72, 767-778.
Marengere, L.E. & Pawson, T. (1992) J Biol Chem 267, 22779-86.
Waksman, G. et al (1993) Cell 72, 779-790.
Biscardi, J.S. et al (1996) J Biol Chem 271:29049-59.
Bottenstein, J.E., and G.H. Sato (1979) Proc Natl Acad Sci USA 76:514-7.
Brewer, G. and C.W. Cotman (1989) Brain Res 494:65-74.
Pelicci, G. et al (1992) Cell 70, 93-104.
Blaikie, P. et al (1994) J Biol Chem 269, 32031-4.
Kavanaugh, W.M. & Williams, L.T. (1994) Science 266, 1862-5.
Songyang, Z et al (1994) Mol. Cell Biol. 14, 2777-2785.
Der Channing
O'Bryan John
Pawson Anthony
Monshipouri Maryam
Mount Sinai Hospital Corporation
University of North Carolina at Chapel Hill
Wax Robert A.
LandOfFree
Shc proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Shc proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Shc proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1850922