Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1994-10-18
1996-11-26
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
424451, 424456, 424464, 424484, 424485, 424486, 424487, 424488, 424492, 424520, A61K 3578, A61K 9127, A61K 964, A61K 914
Patent
active
055783074
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to pellets or true spheres containing plant extract(s) and which comprise a dispersion of the plant extract in a matrix predominantly composed of a skeleton builder of a hydrophilic macromolecule.
The invention furthermore relates to a mild process for the preparation of such pellets or true spheres and to their pharmaceutical, peroral or cosmetic application.
The plant extract which is preferably employed is Aloe vera juice.
The plant extracts in the sense of the present invention are juices from fresh plants obtained directly from the plant, pressed-out juices from fresh plants, either in the original concentration or in concentrated form, filtered and unfiltered, hydrophilic extracts (aqueous or alcoholic extracts, for example ethanol extracts or 1,2-propylene glycol extracts) such as, for example, original tinctures in homeopathy, fluid extracts, macerates, lipophilic extracts (such as, for example, garlic oil), essential oils, complete extracts or specifically standardized extracts (for example standardized to a specific flavone glycoside content), essential oil extracts, individually isolated plant constituents (such as, for example, rutin), synthetic analogs (such as, for example, perfume oils, camphor, thymol, vanillin) and derivatized plant constituents (such as, for example, aglycones).
In individual cases, it is also possible to use dry extracts or the redissolved extract from a dry extract in a suitable solvent, or decoctions prepared therefrom. Pulverized drug constituents (for example leaves, roots, herbaceous parts) can also be processed.
Being natural substances, plant extracts are frequently sensitive to external factors such as light, oxidation by atmospheric oxygen, heat, pH effects in solutions, or microbial contamination. In many plant-derived active substances, it is known that only the fresh juice obtained originally from the plant or parts thereof (for example Echinacea pressed-out juice or Aloe vera juice) have optimum activity. Each means of preservation, such as drying by heat, chemical preservation, heat treatment for preservation purposes and the like adversely affect the delicate plant constituents with regard to their chemical structure and thus their activity. In most cases, preservation against microbial contamination is unavoidable when using fresh plant juices so as to achieve at least limited shelf life.
In addition, the dry matter content of such fresh plant juices is very low, and a large amount of water is being transported or stored.
Lipophilic plant extracts which are sensitive to oxidation, such as vitamin E or garlic oil, are difficult to store in unaltered form and usually have to be processed at once.
Essential oils are volatile and difficult to handle in the form of liquids.
Aloe vera (Aloe barbadensis Miller; synonyms: Aloe vera Tournefort et Linne, Aloe vulgaris Lamarck) has been used for a long time in traditional medicine of those regions in which this plant, which belongs to the family of the Liliaceae grows wild.
If used externally, the gel-like plant juice has, for example, a beneficial effect on wound healing, acts as an antibiotic or has a softening effect on the skin.
Aloe vera juice can be administered internally in the treatment of gastric diseases and disorders of the gastrointestinal tract. Anti-inflammatory properties have also been reported.
These original findings have led to large plantations of Aloe vera having been established in Central America, South America and parts of North America. The juice in the leaves is obtained at the site itself in a laborious process and subsequently concentrated under the mildest possible conditions. The concentration of plant constituents in the freshly obtained juice is between 0.3 and approximately 1%. Fresh Aloe vera fillets, aqueous concentrates or spray- or freeze-dried goods are all commercially available. The differences in quality of commercially available products are considerable with regard to stability and composition and depend largely on the preparation technology e
REFERENCES:
Chem Abstrs. 1/3(13):1/4127d, 1990.
Freidenreich Jurgen
Schick Ursula
Werry Jurgen
Wunderlich Jens-Christian
Alfatec-Pharma GmbH
Rollins John W.
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