SH3 protein, gene, chimeric cells, vectors and expression method

Details SH3 protein, gene, chimeric cells, vectors and expression method SH3 protein, gene, chimeric cells, vectors and expression method

1997-06-09

2000-10-31

Degen, Nancy

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435194, 4353201, 536 231, 536 241, C12P 2102, C07H 2104, C12N 1563, C12N 912

Patent

active

061400742

ABSTRACT:
The invention is a protein having the amino acid sequence of Seq. I.D. No. 1 or an allelic variation retaining the biological activity of the protein having the amino acid sequence of Seq. I.D. No. 1, a DNA segment coding for a protein according to claim 1, preferably DNA segment according to claim 2 having the sequence of Seq. I.D. No. 2, or a substitution analog or allelic variation of Seq. I.D. No. 2, a chimeric cell comprising the DNA segment coding for a protein of Seq. I.D. No. 1, preferably a chimeric cell comprising the DNA segment of Seq. I.D. No. 2, a vector comprising a DNA segment coding for a protein having Seq. I.D. No. 1 operably linked to a promoter. The invention provides a preferred vector comprising the following components operably linked from 5' to 3': (a) a promoter; (b) a signal sequence; (c) 5' portion of a highly expressed gene endogenous to a selected host cell, (d) a linker sequence; all preceding the nucleotide sequence coding for TADG5 protein. The invention provides a protein production method which comprises expressing a DNA segment coding for a protein with the amino acid sequence of Seq. I.D. No. 1 in a chimeric host cell, preferably one which comprises expressing the DNA segment having the sequence of Seq. I.D. No. 2 or a substitution analog. The invention also provides peptides derived from TADG5 protein and further characterized by binding to an oligonucleotide having the sequence selected from the group consisting of Seq. I.D. Nos. 3, 4, 5, 6 7, 8, 9, 10, 11, 12, 13 or a strand complementary to one of the preceding sequences.

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