SF caspase-1 and compositions for making and methods of using th

Details SF caspase-1 and compositions for making and methods of using th SF caspase-1 and compositions for making and methods of using th

1996-12-27

1999-01-12

Wax, Robert A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435219, 4352523, 43525233, 43525411, 4353201, 435348, 536 232, 536 243, 536 2431, C12N 950, C12N 500, C12N 1500, C07H 2104

Patent

active

058587780

ABSTRACT:
A substantially pure protein, Caspase-1, is disclosed. An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes Caspase-1, is disclosed. An isolated nucleic acid molecule consisting of a nucleic acid sequence that encodes Caspase-1, or a fragment thereof having at least 10 nucleotides is disclosed. Recombinant expression vector comprising a nucleic acid sequence that encodes Caspase-1 and host cells comprising the recombinant expression vector are disclosed. Oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleic acid sequence that encodes Caspase-1 of at least 5 nucleotides are disclosed. Antibodies that binds to an epitope on Caspase-1 are disclosed. Methods of identifying modulators and substrates of Caspase-1 are disclosed.

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