Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1994-07-25
1995-08-08
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
424811, 4241521, 4241721, 4241841, 514 21, 435 2, 530350, 5303882, 5303891, A61K 3552, G01N 2164
Patent
active
054393620
ABSTRACT:
A method of sorting living cells based on DNA content. Mammalian sperm subpopulations enriched in X- or Y-sperm. X- and Y-enriched sperm-plasma-membrane vesicles. Substantially pure sex-associated membrane (SAM) proteins. Antibodies binding to X- or Y-SAM proteins, essentially free of antibodies binding to Y- or X-SAM proteins respectively, or to the H-Y antigen. Semen samples enriched for X- or Y-sperm. Methods for increasing the probability that offspring will be male or female comprising the step of allowing as sperm from an enriched semen sample to fertilize an ovum. Methods for increasing the probability that offspring will be male or female comprising the step of immunizing a female with X- or Y-SAM proteins. Methods of decreasing fertility comprising the step of immunizing a female with both X- and Y-sperm. Methods of increasing the probability that mammalian offspring will carry a gene for a particular sex-chromosome linked trait.
REFERENCES:
patent: 3687806 (1972-08-01), Van Den Bovenkamp
patent: 3692897 (1972-09-01), Bhattacharya et al.
patent: 3906929 (1975-09-01), Augspurger
patent: 4083957 (1978-04-01), Lang
patent: 4085205 (1978-04-01), Hancock
patent: 4191749 (1980-03-01), Bryant
patent: 4362246 (1982-12-01), Adair
patent: 4448767 (1984-05-01), Bryant
patent: 4474875 (1984-10-01), Shrimpton
patent: 4680258 (1987-07-01), Hammerling et al.
patent: 4722887 (1988-02-01), Fabricant et al.
patent: 4769319 (1988-09-01), Ellis et al.
patent: 4770992 (1988-09-01), Van den Engh et al.
patent: 5021244 (1991-06-01), Spaulding
patent: 5346990 (1994-09-01), Spaulding
N. J. Alexander and D. J. Anderson, "Immunology of Semen", Fert. and Steril., 47, pp. 192-205 (1987).
G. F. Ames and K. Nikaido, "Two-Dimensional Gel Electrophoresis Of Membrane Proteins", Biochem. 15, pp. 616-623 (1976).
G. B. Anderson, "Identification Of Embryonic Sex By Detection of H-Y Antigen", Theriog., 27, pp. 81-97 (1987).
*D. Bennett and E. Boyse, "Sex Ratio In Progeny Of Mice Inseminated With Sperm Treated With H-Y Antiserum", Nature, 246, pp. 308-309 (1973).
D. Bennett and R. S. Johnson, "Biotech Experts Report Progress In Agricultural Research", in Genetic Engineering News, Sep. (1985).
R. E. Billingham and W. K. Silvers, "Induction of Tolerance Of Skin Isografts From Male Donors In Female Mice", Science, 128, pp. 780-781 (1958) (Billingham-I).
R. E. Billingham et al. "A Second Study On The H-Y Transplantation Antigen In Mice", Proc. Royal Society of London, Series B, Biol. Sci., 163 (1990), pp. 61-89 (1965) pertinent.
H. von Boehmer "Fine Specificity Of A Continuously Growing Killer Cell Clone Specific For H-Y Antigen", Eur. J. Immunol., 9, pp. 592-597 (1979).
E. A. Boyse and D. Bennett, "Differentiation And The Cell Surface; Illustrations From Work With T Cells And Sperm", in Cellular Selection and Regulation In The Immune Response, G. M. Edelman ed., Raven Press, New York, pp. 155-176 (1974).
F. Bradley et al., "Structural Proteins Of The Mouse Spermatozoan Tail: An Electrophoretic Analysis", Biol. Reprod., 24, pp. 691-701 (1981).
M. P. Bradley and B. F. Heslop, "A Biochemical And Immunological Approach To The Identification Of H-Y Antigenic Proteins Secreted From Daudi Cells", Hum. Genet., 71, pp. 117-121, (1985).
B. F. Brandriff et al., "Sex Chromosome Ratios Determined By Karyotypic Analysis In Albumin-Isolated Human Sperm", Fertil. Steril., 46, pp. 678-685 (1986).
*G. Braun et al., "Method and Apparatus for Fluorometric Determination of the Amount of Material Embedded in Particles", Appl. 260,742, (1984), Chem. Abstracts, 104, #17532e, p. 282 (1986) (Braun).
M. Brunner et al., "On The Secretion of H-Y Antigen", Cell, 37, pp. 615-619 (1984).
*D. N. Crichton and B. B. Cohen, "Analysis Of The Murine Sperm Surface With Monoclonal Antibodies", J. Reprod. Fert., 68, pp. 497-505 (1983).
*W. P. Dmowski et al., "Use Of Albumin Gradients For X and Y Sperm Separation And Clinical Experience With Male Sex Preselection", Fertil. Steril., 31, pp. 52-57 (1979).
E. M. Eddy and J. K. Koehler, "Restricted Domains Of The Sperm Surface" in Scanning Electron Microscopy, Sem. Inc. AMF O'Hare, Ill. pp. 1313-1323 (1982).
*R. J. Ericsson et al., "Isolation Of Fractions Rich In Human Y Sperm", Nature, 246, pp. 421-424 (1983).
H. J. Evans, "Properties of Human X and Y Sperm", Proc. Int. Symp. Gen. Sperm., pp. 144-159 (1972).
"Farm Flashes . . . Seasonal Reminders and Research: Machine Sorts Semen For Sex Selection", Hoard's Dairyman, Mar. 25, 1988.
E. H. E. Frost et al., "Radioactive Labelling of Viruses: An Iodination Technique Preserving Biological Properties", J. Gen. Virol., 35, pp. 181-185 (1977).
D. L. Garner et al., "Quantification Of The X-and Y-Chromosome-Bearing Spermatozoa of Domestic Animals By Flow Cytometry", Biol. Repro., 28, pp. 312-321 (1983) (Garner-I).
*D. L. Garner et al., "An Overview of Separation of X- and Y-Spermatozoa", Proceedings of the Tenth Technical Conference on Artificial Insemination and Reproduction (National Association of Animal Breeders), pp. 87-92 (1984) (Garner-II).
G. Gillis et al., "Isolation And Characterization Of Membrane Vesicles From Human And Boar Spermatozoa: Methods Using Nitrogen Cavitation And Ionophore Induced Vesiculation", Prep. Bioch., 8, pp. 363-378 (1978).
*B. Gledhill, "Cytometry Of Mammalian Sperm", Gamete Research, 12, pp. 423-438 (1985) (Gledhill I).
B. L. Gledhill, "Selection and Separation of X- and Y-Chromosome-Bearing Mammalian Sperm", Gamete Res., 20, pp. 377-395 (1988) (Gledhill II).
E. H. Goldberg et al., "Serological Demonstration Of H-Y (Male) Antigen On Mouse Sperm", Nature, 232, pp. 478-480 (1971) (Goldberg-I).
E. Goldberg, "Current Status Of Research On Sperm Antigens: Potential Applications As Contraceptive Vaccines", Res. Front. Fert. Reg., 2, pp. 1-11 (1983) (Goldberg-II).
Hafs and Boyd, "Sex Ratio at Birth--Prospects for Control" Am. Soc. Anim. Sci. pp. 85-97 (1971).
J. I. Hall and S. S. Wachtel, "Primary Sex Determination: Genetics And Biochemistry", Mol. Cell. Biochem., 33, pp. 49-66 (1980).
T. S. Hauschka and B. A. Holdridge, "A Cytogenetic Approach To The Y-Linked Histocompatibility Antigen Of Mice", Ann. N.Y. Acad. Sci., 101, pp. 12-23 (1962).
U. Hegde et al., "Phytohaemagglutinin As A Molecular Probe To Study The Membrane Constituents Of Human X-And Y-Bearing Spermatozoa", J. Rep. Immun., 2, pp. 351-357 (1981).
A. C. Hinrichsen-Kohane, "Analysis Of Antigen Expression On Human Spermatozoa By Means Of Monoclonal Antibodies", Fertil. Steril., 43, pp. 279-285 (1985).
*P. Hoppe and G. C. Koo, "Reacting Mouse Sperm With Monoclonal H-Y antibodies Does Not Influence Sex Ratio Of Eggs Fertilized In Vitro", J. Rep. Immun., 6, pp. 1-9 (1984).
E. N. Hughes and J. T. August, "Characterization Of Plasma Membrane Proteins Identified By Monoclonal Antibodies", J. Biol. Chem., 256, pp. 664-671 (1981).
**W. P. Hunt et al., "Isolation of Major Proteins from Boar Sperm Plasma Membranes by Preparative Gel Electrophoresis and Localization of a Major Polypeptide Using Specific Monoclonal Antibodies", Prep. Biochem., 15, pp. 9-33 (1985) (Hunt).
***L. A. Johnson et al., "Flow Sorting of X and Y Chormosome-Bearing Spermatozoa Into Two Populations", Gamete Research, 16, pp. 1-9 (1987) (copy enclosed).
L. A. Johnson and D. Pinkel, "Modification Of A Laser-Based Flow Cytometer For High Resolution DNA Analysis Of Mammalian Spermatozoa", Cytom., 7, pp. 268-273 (1986).
*D. J. Arndt-Jovin and T. Jovin, "Analysis And Sorting Of Living Cells According To Deoxyribonucleic Acid Content", J. Histochem. Cytochem., 25, 585-589 (1977).
*G. P. R. Kaiser et al., "Relative Increase in Y-Chromatin-Bearing Spermatozoa After In Vitro Penetration into Human Cervical Mucus", IRCS, 2, p. 1100 (1974).
*G. C. Koo et al., "Expression Of H-Y Antigen During Spermatogensis", Immunogen., 9, pp. 293-296 (1979) (Koo-I).
G. C. Koo et al., "Topographical Loacation Of H-Y Antigen On Mouse Spermatozoa By Immunoelectronmicroscopy", Proc. Nat. Acad. Sci., 70, pp. 1502-1505 (1973) (Koo-II).
G. C. Koo and A. Varano, "Inhibition Of H-Y Cell-Mediated Cytolysis By Monoclonal H-Y Specific Antibody", Immunoge
Cytogam, Inc.
Haley, Jr. James F.
Schain Howard E.
Schofield Mary Anne
Touzeau P. Lynn
LandOfFree
Sex-associated membrane proteins and methods for increasing the does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sex-associated membrane proteins and methods for increasing the , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sex-associated membrane proteins and methods for increasing the will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-967706