Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1999-04-26
2000-08-22
Houtteman, Scott W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 71, 4353201, 530360, 53038832, C07H 2104
Patent
active
061074756
ABSTRACT:
DNA sequences encoding seven novel seven transmembrane receptors and variants thereof are disclosed as well as materials and methods for production of the same by recombinant techniques. Antibody substances specific for each of the seven transmembrane receptors are disclosed as useful for the modulation of the ligand/receptor binding reactions of the receptors.
REFERENCES:
Allen et al., "G-Protein-Coupled Receptor Genes as Protooncogenes: Constitutively Activating Mutation of the .alpha..sub.1B -Adrenergic Receptor Enhances Mitogenesis and Tumorigenicity," Proc. Natl. Acad. Sci., USA, 88:11354-11358 (1991).
Alper, "Oligonucleotides Surge into Clinical Trails," Bio/Technology, 11:1225 (1993).
Arai et al., "Cloning and Expression of a cDNA Encoding an Endothelin Receptor," Nature, 348:730-732 (1991).
Benoist et al., "The Ovalbumin Gene--Sequence of Putative Control Regions," Nucleic Acids Research, 8:127-142 (1980).
Birkenbach et al., "Epstein-Barr Virus-Induced Genes: First Lymphocyte-Specific G Protein-Coupled Peptide Receptors," Journal of Virology, 67(4):2209-2220 (1993).
Blin et al., "A General Method for Isolation of High Molecular Weight DNA from Eukaryotes," Nucleic Acids Research, 3(9):2303-2308 (1976).
Boulay, "Synthesis and Use of a Novel N-Formyl Peptide Derivative to Isolate a Human N-Formyl Peptide Receptor cDNA," Biochem. Biophys. Res. Comm., 168:1103-1109 (1990).
Burbach et al., "The Structure of Neuropeptide Receptors," European Journal of Pharmacology, 227:1-18 (1992).
Cherif et al., "Detection of Single-Copy Genes by Nonisotopic in Situ Hybridization of Human Chromosomes," Hum. Genet., 81:358-362 (1989).
Chirgwin et al., "Isolation of Biologically Active Ribonucleic Acid from Sources Enriched in Ribonuclease," Biochemistry, 18(24):5294-5299 (1979).
Chomczynski, "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction," Analytical Biochemistry, 162:156-159 (1987).
Cotecchia et al., "Regions of the .alpha..sub.1 -Adrenergic Receptor Involved in Coupling to Phosphatidylinositol Hydrolysis and Enhanced Sensitivity of Biological Function," Proc. Natl. Acad. Sci., USA, 87:2896-2900 (1990).
Crooke et al., "Therapeutic Applications of Oligonucleotides," Bio/Technology, 10:882-886 (1992).
Dohlman et al., "Model Systems for the Study of Seven-Transmembrane Segment Receptors," Ann. Rev. Biochem., 60:653-688 (1991).
Downes et al., "The Polyphosphoinositide Phosphodiesterase of Erythrocyte Membranes," Biochem. J., 198:133-140 (1981).
EMBL 44 Data Bank Accession No. M99293, Aug. 19, 1992 (rel. 33, created) Federsppiel et al.
EMBL 44 Data Bank Accession No. L01639, Sep. 14, 1992 (rel. 33, created), Janzin et al.
EMBL 44 Data Bank Accession No. D10924, Jul. 16, 1992 (rel. 32, created), Nomura et al.
Fan et al., "Mapping Small DNA Sequences by Fluorescence in situ Hybridization Directly on Banded Metaphase Chromosomes," Proc. Natl. Acad. Sci., USA, 87:6223-6227 (1990).
Federsppiel et al., "Molecular Cloning of the cDNA and Chromosomal Localization of the Gene for a Putative Seven-Transmembrane Segment (7-TMS) Receptor Isolated from Human Spleen," Genomics, 16:707-712 (1993).
Findeis et al., "Targeted Delivery of DNA for Gene Therapy via Receptors," TIBTECH, 11:202-205 (1993).
Gerard, "The Chemotactic Receptor for Human C5a Anaphylatoxin," Nature, 349:614-617 (1991).
Hall et al., "Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21,"Science, 250:1684-1689 (1990).
Higuchi, R., "Using PCR to Engineer DNA," in PCR Technology, Chapter 6, Erlich, Ed., Stockton Press, New York, pp. 61-70 (1989).
Hirata et al., "Cloning and Expression of cDNA for a Human Thromboxane A.sub.2 Receptor," Nature, 349:617-620 (1991).
Holmes et al., "Structure and Functional Expression of a Human Interleukin-8 Receptor," Science, 253:1278-1280 (1991).
Honda et al., "Cloning by Functional Expression of Platelet-activating Factor Receptor from Guinea-pig Lung," Nature, 349:342-346 (1991).
Jazin et al., "A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites not NPY responsiveness on transfected cells," Regulatory Peptides, 47:247-258 (1993).
Julius et al., "Ectopic Expression of the Serotonin lc Receptor and the Triggering of Malignant Transformation," Science, 244:1057-1062 (1989).
Khorana, "Rhodopsin, Photoreceptor of the Rod Cell," J. Biol. Chem., 267:1-4 (1992).
Kozak, "Compilation and Analysis of Sequences Upstream from the Translational Start Site in Eukaryotic mRNAs," Nucleic Acids Research, 12(2):857-872 (1984).
Lefkowitz, "Turned on to Ill Effect," Nature, 365:603-604 (1993).
Libert, "Selective Amplification and Cloning of Four New Members of the G Protein-Coupled Receptor Family," Science, 244:569-572 (1989).
Linder et al., "G Proteins: Tucked into the Internal Surface of the Cell's Outer Membrane, These Versatile Molecules Coordinate Cellular Responses to a Multitude of Signals that Impinge from Without," Scientific American, 267:56-65 (1992).
Mitani et al., "Delivering Therapeutic Genes--Matching Approach and Application," TIBTECH, 11:162-166 (1993).
Murphy et al., "Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor," Science, 253:1280-1283 (1991).
Murphy et al., "Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor," Nature, 351:233-236 (May, 1991).
Naylor et al., "Human Immune Interferon Gene is Located on Chromosome 12," J. Exp. Med., 57:1020-1027 (1983).
Neote et al., "Molecular Cloning , Functional Expression, and Signaling Characteristics of a C-C Chemokine Receptor," Cell, 72:415-425 (1993).
Nomura et al., "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors," International Immunology, 5(10):12389-1249 (1993).
Nomura et al., "Molecular Cloning of Complementary DNAs for Putative Chemotactic Polypeptide Receptor Family," 8th International Congress of Immunology, Budapest, Hungary (Aug. 23-28, 1992).
O'Brien, Ed., in Genetic Maps: Locus Maps of Complex Genomes, Sixth Edition, Book 5, Human Maps, Cold Spring Harbor Laboratory Press, Plainview, New York, pp. 5.108-5.109 (1993).
Parma et al., "Somatic Mutations in the Thyrotropin Receptor Gene Cause Hyperfunctioning Thyroid Adenomas," Nature, 365:649-651 (1993).
Probst et al., "Sequence Alignment of the G-Protein Coupled Receptor Superfamily," DNA and Cell Biology, 11(1):1-20 (1992).
Raport et al., "The Orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues," Gene, 163:295-299 (1995).
Robinson et al., "Constitutively Active Mutants of Rhodopsin," Neuron, 9:719-725 (Oct., 1992).
Rosenthal et al., "Nephrogenic Diabetes Insipidus: A V2 Vasopressin Receptor Unable to Stimulate Adenylyl Cyclase," J. Biol. Chem., 268:13030-13033 (1993).
Ruat et al., "Molecular Cloning, Characterization, and Localization of a High-Affinity Serotonin Receptor (5-HT.sub.7) Activating cAMP Formation," Proc. Natl. Acad. Sci., USA, 90:8547-8551 (1993).
Sasaki et al., "Cloning and Expression of a Complementary DNA Encoding a Bovine Adrenal Angiotensin II Type-1 Receptor," Nature, 351:230-233 (1991).
Shenker et al., "A Constitutively Activating Mutation of the Lutenizing Hormone Receptor in Familial Male Precocious Puberty," Nature, 365:652-654 (1993).
Sikora, "Gene Therapy for Cancer," TIBTECH, 11:197-201 (1993).
Smith et al., "Single-step Purification of Polypeptides Expressed in Escherichia coli as Fusions with Glutathione S-transferase," Gene, 67:31-40 (1988).
Styer, "Visual Excitation and Recovery," J. Biol. Chem., 266(17):10711-10714 (1991).
Thomas et al., "Molecular Cloning of the fMet-Leu-Phe Receptor from Neutorphils," J. Biol. Chem., 265(33):20061-20064 (1990).
Vu et al., "Molecular Cloning of a Functional Thrombin Receptor Reveals a Novel Proteolytic Mechanism of Receptor Activation," Cell, 64:1057-1068 (1991).
Wada et al., "Codon usage tabulated from the GenBank genetic sequence data," Nucl. Acids Res., 19S:1981-1986 (1991).
Yamada et al., "Cloning and
Godiska Ronald
Gray Patrick W.
Schweickart Vicki Louise
Houtteman Scott W.
ICOS Corporation
LandOfFree
Seven transmembrane receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Seven transmembrane receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Seven transmembrane receptors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-582606