Sesquiterpene synthases and methods of use

Details Sesquiterpene synthases and methods of use Sesquiterpene synthases and methods of use

2007-09-25

2007-09-25

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing hydrocarbon

C435S155000, C435S006120, C435S488000, C435S193000, C435S069100, C435S320100, C536S023200

Reexamination Certificate

active

11094607

ABSTRACT:
The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various oxygenated and aliphatic sesquiterpenes including valencene, bicyclo-germacrene, cubebol and delta-cadinene.

REFERENCES:
patent: 1 040 765 (2000-10-01), None
patent: WO2005/021705 (2005-03-01), None
Xia et al. (UniProt Q8RVR2, Putative terpene synthase, created Jun. 1, 2002).
Guo et al. Protein tolerance to random amino acid chang, Proc Natl Acad Sci U S A, Jun. 22, 2004; 101(25): 9205-10, Epub Jun. 14, 2004.
Abstract: D. Xia et al., XP 002304705, “Putative Terpene Synthase”, PRT, 548 AA, (2002).
Abstract: XP 002282507, “Isolation Of A Terpene Synthase Gene From Mature ‘Rio Red’ grapefruit using differential display” (2001).
Liat Sharon-Asa et al., XP-002282506, “Citrus Fruit Flavor And Aroma Biosynthesis: Isolation, Functional Characterization, And Developmental Regulation Of Cstps 1, A Key Gene In The Production Of The Sesquiterpene Aroma Compound Valencene”, The Plant Journal, vol. 36, pp. 664-674 (2003).
Susan C. Trapp et al, XP-002282505, “Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications”, Genetics Society of America, vol. 158, pp. 811-832, (2001).
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Takuro Maruyama et al., XP-002282504, “Molecular Cloning, Functional Expression and Characterization of (E)-βFarnesene Synthase fromCitrus junos”, Biol. Pharm. Bull., vol. 24, No. 10, pp. 1171-1175( 2001).

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